ArticlePloS one2015
Delta neutrophil index as a promising prognostic marker in out of hospital cardiac arrest.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Article
- Clinical characteristics of patients with cardiogenic shock after out-of-hospital cardiac arrest (OHCA) compared to patients with cardiogenic shock without OHCA.Cardiology journal · 2026Article
- Splenic modulation of the early inflammatory response to regional and global ischemia/reperfusion injury in swine.American journal of physiology. Heart and circulatory physiology · 2025Article
- Delta Neutrophil Index in Coronary Artery Bypass Surgery: An Innovation in Postoperative Mortality Assessment.Journal of inflammation research · 2025Article
- Intra-arrest blood-based biomarkers for out-of-hospital cardiac arrest: A scoping review.Journal of the American College of Emergency Physicians open · 2024Article
- Association of Delta Neutrophil Index with the 30-day Mortality in Adult Cardiac Surgical Patients.International journal of medical sciences · 2024Article
- Delta neutrophil index in obese and non-obese polycystic ovary syndrome patients.Obstetrics & gynecology science · 2023Article
- Thrombotic Microangiopathy Score as a New Predictor of Neurologic Outcomes in Patients after Out-of-Hospital Cardiac Arrest.Yonsei medical journal · 2022Article
- Delta Neutrophil Index and Neutrophil-to-Lymphocyte Ratio in the Differentiation of Thyroid Malignancy and Nodular Goiter.World journal of surgery · 2021Article
- Gamma-Glutamyl Transpeptidase to Platelet Ratio: A New Inflammatory Marker Associated with Outcomes after Cardiac Arrest.Mediators of inflammation · 2021Article
- The Effect of Emergency Department Visits and Inflammatory Markers on One-Year Mortality in Patients with Heart Failure.Cardiovascular toxicology · 2021Article
- Association between Novel Marker (Platelet-Lymphocyte Ratio, Neutrophil-Lymphocyte Ratio, and Delta Neutrophil Index) and Outcomes in Sudden Cardiac Arrest Patients.Emergency medicine international · 2021Article
- Observational
- Lung SOD3 limits neurovascular reperfusion injury and systemic immune activation following transient global cerebral ischemia.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2020Article
- Immature Granulocyte Count and Percentage as New Predictors of Mortality in Patients with Upper Gastrointestinal Bleeding.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020Article
- Predictors and outcomes of sepsis-induced cardiomyopathy in critically ill patients.Acute and critical care · 2020Article
- Prognostic value of the delta neutrophil index in pediatric cardiac arrest.Scientific reports · 2020Article
- Delta neutrophil index for predicting mortality in trauma patients who underwent emergent abdominal surgery: A case controlled study.PloS one · 2020Article
- The Delta Neutrophil Index Predicts the Development of In-hospital Hypotension in Initially Stable Patients with Pyogenic Liver Abscess.Scientific reports · 2019Article
- Number of Circulating CD 73-Expressing Lymphocytes Correlates With Survival After Cardiac Arrest.Journal of the American Heart Association · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe post-resuscitation phase after out-of-hospital cardiac arrest (OHCA) is characterised by a systemic inflammatory response (e.g., severe sepsis), for which the immature granulocyte count is a diagnostic marker. In this study we evaluated the prognostic significance of the delta neutrophil index (DNI), which is the difference in leukocyte subfractions as assessed by an automated blood cell analyser, for early mortality after OHCA. MATERIALS AND
methodsOHCA records from the emergency department cardiac arrest registry were retrospectively analysed. Patients who survived at least 24 h after return of spontaneous circulation were included in the analysis. We evaluated mortality and cerebral performance category scores at 30 days.
resultsA total of 83 patients with OHCA were included in the study. Our results showed that DNI >8.4% on day 1 (hazard ratio [HR], 3.227; 95% CI, 1.485-6.967; p = 0.001) and DNI >10.5% on day 2 (HR, 3.292; 95% CI, 1.662-6.519; p<0.001) were associated with increased 30-day mortality in patients with OHCA. Additionally, DNI >8.4% on day 1 (HR, 2.718; 95% CI, 1.508-4.899; p<0.001) and DNI >10.5% on day 2 (HR, 1.709; 95% CI, 1.051-2.778; p = 0.02) were associated with worse neurologic outcomes 30 days after OHCA.
conclusionA higher DNI is a promising prognostic marker for 30-day mortality and neurologic outcomes after OHCA. Our findings indicate that patients with elevated DNI values after OHCA might be closely monitored so that appropriate treatment strategies can be implemented.
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