Evidence map›Paper›PMID 25798607›Full record

ArticlePloS one2015

Incidence of HIV and the prevalence of HIV, hepatitis B and syphilis among youths in Maputo, Mozambique: a cohort study.

Edna Omar Viegas, Nelson Tembe, Eulália Macovela, Emília Gonçalves, Orvalho Augusto, Nália Ismael, Nádia Sitoe, Caroline De Schacht, Nilesh Bhatt, Bindiya Meggi and 7 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 2 countries.

Edna Omar ViegasInstituto Nacional de Saúde, Maputo, Mozambique; Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden; Faculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mozambique.
Nelson TembeInstituto Nacional de Saúde, Maputo, Mozambique; Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden; Faculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mozambique.
Eulália MacovelaFaculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mozambique; Hospital Central de Maputo, Maputo, Mozambique.
Emília GonçalvesFaculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mozambique; Hospital Central de Maputo, Maputo, Mozambique.
Orvalho AugustoFaculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mozambique.
Nália IsmaelInstituto Nacional de Saúde, Maputo, Mozambique.
Nádia SitoeInstituto Nacional de Saúde, Maputo, Mozambique.
Caroline De SchachtElizabeth Glaser Pediatric AIDS Foundation, Maputo, Mozambique.
Nilesh BhattInstituto Nacional de Saúde, Maputo, Mozambique.
Bindiya MeggiInstituto Nacional de Saúde, Maputo, Mozambique.
Carolina AraujoFaculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mozambique.
Eric SandströmDepartment of Education and Clinical Research, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden.
Gunnel BiberfeldPublic Health Agency of Sweden, Solna, Sweden; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Charlotta NilssonDepartment of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden; Public Health Agency of Sweden, Solna, Sweden; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Sören AnderssonDepartment of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Ilesh JaniInstituto Nacional de Saúde, Maputo, Mozambique.
Nafissa OsmanFaculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mozambique; Hospital Central de Maputo, Maputo, Mozambique.
Eduardo Mondlane University · MZInstituto Nacional de Saúde · MZKarolinska Institutet · SEFundação Ariel Glaser Contra o SIDA Pediátrico · MZMaputo Central Hospital · MZÖrebro University · SEPublic Health Agency of Sweden · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevalence of HIV in Mozambique among individuals aged 15-49 years is 11.5%. The HIV prevalence is higher in women than in men across the country, peaking at ages 25-29 years and 35-39 years, respectively. In this study, we aimed at determining the prevalence and incidence of HIV, prevalence of Hepatitis B (HBV), and prevalence of syphilis in youths. We also characterized a cohort of youths for future participation in phase I/II HIV vaccine trials.

methodsThe study was conducted at a youth clinic in Maputo Central Hospital from August 2009 to October 2011. Youths of both genders aged 18-24 years (n = 1380) were screened for HIV using a sequential algorithm of two immunochromatographic assays, HBV using an enzyme linked immunosorbant test, and syphilis using a treponemal immunochromatographic strip test. The HIV seronegative participants (n = 1309) were followed-up for 12 months with quarterly study visits. The clinical and behavioral data were collected using structured questionnaires. The HIV seroconversions were confirmed by a molecular assay.

resultsThe study population was female dominant (76.8%). All participants had a formal education, with 44.6% studying for technical or higher education degrees. The mean age at sexual debut was 16.6 years (SD: ± 1.74), with 85.6% reporting more than one sexual partner in life. The screening showed the prevalence of HIV, HBV, and syphilis at 5.1% (95% CI: 3.97-6.31), 12.2% (95% CI 10.5%-14.0%), and 0.36% (95% CI 0.15%-0.84%), respectively. The HIV incidence rate was found to be 1.14/100 person years (95% CI: 0.67-1.92). Retention rates were stable throughout the study being 85.1% at the last visit.

conclusionIncidence of HIV in this cohort of youths in Maputo was relatively low. Also, the prevalence of HIV and syphilis was lower than the national values in this age group. However, the HBV prevalence was higher than in previous reports in the country.

Indexed as

AdolescentFemaleHepatitis BHIV InfectionsHumansIncidenceMaleMozambiquePrevalenceProspective StudiesSyphilisViral LoadYoung Adult

Identifiers

PMID25798607
PMCPMC4370560
OpenAlexW1987958659

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.