ArticleBiomedical optics express2015
Technique for real-time tissue characterization based on scanning multispectral fluorescence lifetime spectroscopy (ms-TRFS).
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Intraoperative Mapping of Parathyroid Glands Using Fluorescence Lifetime Imaging.The Journal of surgical research · 2021Trial
- Intraoperative detection of IDH-mutant glioma using fluorescence lifetime imaging.Journal of biophotonics · 2023Article
- Multispectral fluorescence lifetime imaging device with a silicon avalanche photodetector.Optics express · 2021Article
- Mesoscopic fluorescence lifetime imaging: Fundamental principles, clinical applications and future directions.Journal of biophotonics · 2021Review
- Dual-modality optical coherence tomography and frequency-domain fluorescence lifetime imaging microscope system for intravascular imaging.Journal of biomedical optics · 2020Article
- Real-time diagnosis and visualization of tumor margins in excised breast specimens using fluorescence lifetime imaging and machine learning.Biomedical optics express · 2020Article
- Real-time augmented reality for delineation of surgical margins during neurosurgery using autofluorescence lifetime contrast.Journal of biophotonics · 2020Article
- Multiscale, multispectral fluorescence lifetime imaging using a double-clad fiber.Optics letters · 2019Article
- Autofluorescence lifetime augmented reality as a means for real-time robotic surgery guidance in human patients.Scientific reports · 2019Article
- Detection of glycosaminoglycan loss in articular cartilage by fluorescence lifetime imaging.Journal of biomedical optics · 2018Article
- Label-free fluorescence lifetime spectroscopy detects radiation-induced necrotic changes in live brain in real-time.Biomedical optics express · 2018Article
- Time-resolved fluorescence spectroscopy for the diagnosis of oral lichen planus.Clinical and experimental dermatology · 2018Article
- Fiber pattern removal and image reconstruction method for snapshot mosaic hyperspectral endoscopic images.Biomedical optics express · 2018Article
- Automated detection of breast cancer in resected specimens with fluorescence lifetime imaging.Physics in medicine and biology · 2017Article
- Label-free optical imaging technologies for rapid translation and use during intraoperative surgical and tumor margin assessment.Journal of biomedical optics · 2017Review
- Rapid fluorescence lifetime estimation with modified phasor approach and Laguerre deconvolution: a comparative study.Methods and applications in fluorescence · 2017Article
- In vivo label-free structural and biochemical imaging of coronary arteries using an integrated ultrasound and multispectral fluorescence lifetime catheter system.Scientific reports · 2017Article
- Real-Time Visualization of Tissue Surface Biochemical Features Derived From Fluorescence Lifetime Measurements.IEEE transactions on medical imaging · 2016Article
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Authors and funding
5 authors.
Funding
Abstract
We report a novel technique for continuous acquisition, processing and display of fluorescence lifetimes enabling real-time tissue diagnosis through a single hand held or biopsy fiber-optic probe. A scanning multispectral time-resolved fluorescence spectroscopy (ms-TRFS) with self-adjustable photon detection range was developed to account for the dynamic changes of fluorescence intensity typically encountered in clinical application. A fast algorithm was implemented in the ms-TRFS software platform, providing up to 15 Hz continuous display of fluorescence lifetime values. Potential applications of this technique, including biopsy guidance, and surgical margins delineation were demonstrated in proof-of-concept experiments. Current results showed accurate display of fluorescence lifetimes values and discrimination of distinct fluorescence markers and tissue types in real-time (< 100 ms per data point).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.