ArticleBiomedical optics express2015
Optimizing modulation frequency for structured illumination in a fiber-optic microendoscope to image nuclear morphometry in columnar epithelium.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Feasibility of clinical detection of cervical dysplasia using angle-resolved low coherence interferometry measurements of depth-resolved nuclear morphology.International journal of cancer · 2017Trial
- Usability of a smartphone-compatible, confocal micro-endoscope for cervical cancer screening in resource-limited settings.BMC women's health · 2024Article
- Low-cost, chromatic confocal endomicroscope for cellular imagingBiomedical optics express · 2021Article
- Reduced motion artifacts and speed improvements in enhanced line-scanning fiber bundle endomicroscopy.Journal of biomedical optics · 2021Article
- Automatic motion compensation for structured illumination endomicroscopy using a flexible fiber bundle.Journal of biomedical optics · 2020Article
- Line-scanning confocal microendoscope for nuclear morphometry imaging.Journal of biomedical optics · 2017Article
- Fluorescence confocal endomicroscopy of the cervix: pilot study on the potential and limitations for clinical implementation.Journal of biomedical optics · 2016Article
- Differential structured illumination microendoscopy for in vivo imaging of molecular contrast agents.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Line-scanning fiber bundle endomicroscopy with a virtual detector slit.Biomedical optics express · 2016Article
- Diffuse optical microscopy for quantification of depth-dependent epithelial backscattering in the cervix.Journal of biomedical optics · 2016Article
- Article
- Fiber-bundle microendoscopy with sub-diffuse reflectance spectroscopy and intensity mapping for multimodal optical biopsy of stratified epithelium.Biomedical optics express · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Fiber-optic microendoscopes have shown promise to image the changes in nuclear morphometry that accompany the development of precancerous lesions in tissue with squamous epithelium such as in the oral mucosa and cervix. However, fiber-optic microendoscopy image contrast is limited by out-of-focus light generated by scattering within tissue. The scattering coefficient of tissues with columnar epithelium can be greater than that of squamous epithelium resulting in decreased image quality. To address this challenge, we present a small and portable microendoscope system capable of performing optical sectioning using structured illumination (SI) in real-time. Several optical phantoms were developed and used to quantify the sectioning capabilities of the system. Columnar epithelium from cervical tissue specimens was then imaged ex vivo, and we demonstrate that the addition of SI achieves higher image contrast, enabling visualization of nuclear morphology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.