ArticleBiomedical optics express2015
Significant correlation between refractive index and activity of mitochondria: single mitochondrion study.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Label-free 4D holotomography with depth-adaptive segmentation for quantitative analysis of lipid droplet dynamics in hepatic organoids.Biophotonics discovery · 2026Article
- BCR::ABL1-induced mitochondrial morphological alterations as a potential clinical biomarker in chronic myeloid leukemia.Cancer science · 2025Article
- Metabolic reprogramming via mitochondrial delivery for enhanced maturation of chemically induced cardiomyocyte-like cells.MedComm · 2024Article
- Photonic Artifacts in Ratiometric Luminescence Nanothermometry.Nano letters · 2023Article
- Intrinsic signal optoretinography of dark adaptation kinetics.Scientific reports · 2022Article
- Interpretation of anatomic correlates of outer retinal bands in optical coherence tomography.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- In vivo optoretinography of phototransduction activation and energy metabolism in retinal photoreceptors.Journal of biophotonics · 2021Article
- Visible Light Optical Coherence Tomography (OCT) Quantifies Subcellular Contributions to Outer Retinal Band 4.Translational vision science & technology · 2021Article
- Micromanipulation of amyloplasts with optical tweezers inPlant biotechnology (Tokyo, Japan) · 2020Article
- A Toolbox for Organelle Mechanobiology Research-Current Needs and Challenges.Micromachines · 2019Article
- Adaptive wavefront correction structured illumination holographic tomography.Scientific reports · 2019Article
- Label-free classification of neurons and glia in neural stem cell cultures using a hyperspectral imaging microscopy combined with machine learning.Scientific reports · 2019Article
- A nanoscale, multi-parametric flow cytometry-based platform to study mitochondrial heterogeneity and mitochondrial DNA dynamics.Communications biology · 2019Article
- A protonic biotransducer controlling mitochondrial ATP synthesis.Scientific reports · 2018Article
- Sizing lipid droplets from adult and geriatric mouse liver tissue via nanoparticle tracking analysis.Analytical and bioanalytical chemistry · 2018Article
- Label-free and live cell imaging by interferometric scattering microscopy.Chemical science · 2018Article
- Temporal depolarization of mitochondria during M phase.Scientific reports · 2017Article
- Near-Membrane Refractometry Using Supercritical Angle Fluorescence.Biophysical journal · 2017Article
- Partial contribution of mitochondrial permeability transition toBiochemistry and biophysics reports · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Measurements of refractive indices (RIs) of intracellular components can provide useful information on the structure and function of cells. The present study reports, for the first time, determination of the RI of an isolated mitochondrion in isotonic solution using retardation-modulated differential interference contrast microscopy. The value was 1.41 ± 0.01, indicating that mitochondria are densely packed with molecules having high RIs. Further, the RIs of each mitochondrion were significantly correlated with the mitochondrial membrane potential, an index of mitochondrial activity. These results will provide useful information on the structures and functions of cells based on the intracellular distribution of RIs.
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