ArticleBiomedical optics express2015
Optically investigating Nd(3+)-Yb(3+) cascade sensitized upconversion nanoparticles for high resolution, rapid scanning, deep and damage-free bio-imaging.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Lanthanide ion-doped upconversion nanoparticles for low-energy super-resolution applications.Light, science & applications · 2024Review
- Near-infrared light excited photodynamic anticancer therapy based on UCNP@AIEgen nanocomposite.Nanoscale advances · 2021Article
- 3D sub-diffraction imaging in a conventional confocal configuration by exploiting super-linear emitters.Nature communications · 2019Article
- Macrophage-mediated delivery of light activated nitric oxide prodrugs with spatial, temporal and concentration control.Chemical science · 2018Article
- Lanthanide-Doped Upconversion Nanoparticles: Emerging Intelligent Light-Activated Drug Delivery Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2016Article
- Designed Er(3+)-singly doped NaYF4 with double excitation bands for simultaneous deep macroscopic and microscopic upconverting bioimaging.Biomedical optics express · 2016Article
- Deep, high contrast microscopic cell imaging using three-photon luminescence of β-(NaYF4:Er(3+)/NaYF4) nanoprobe excited by 1480-nm CW laser of only 1.5-mW.Biomedical optics express · 2015Article
Corrections and comments
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The rapid development of upconversion nanoparticles (UCNPs) has been facing with a great challenge: intense emission, fast scanning, and deep imaging require high-power light irradiation with minimized heating effect (the intrinsic 975-nm excitation of Yb(3+)-sensitized UCNPs have overheating problem). By shifting the excitation peak from 975 nm to 795 nm, Nd(3+)-Yb(3+) cascade sensitized upconversion nanoparticles (Nd-UCNPs) with minimized heating effect were reported as the new generation UCNPs. For the first time, within two optically modeled applications in vitro and in vivo, the damage outcomes under long time high power laser excitation were solidly calculated, complementing the damage-free study of Nd-UCNPs. The higher resolution (20% improvement) and five times faster scanning microscopy were successfully performed using Nd-UCNPs under safety laser power level. The computational results showed the Nd(3+)-Yb(3+) energy transfer efficiency would not compromise the deep imaging ability, and the red (650-nm) emission is worth to be enhanced for deep tissue imaging.
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