ArticleBiomedical optics express2015
Next-generation Raman tomography instrument for non-invasive in vivo bone imaging.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges.ACS applied materials & interfaces · 2025Review
- Label-free 3D molecular imaging of living tissues using Raman spectral projection tomography.Nature communications · 2024Article
- Advancing Brain Research through Surface-Enhanced Raman Spectroscopy (SERS): Current Applications and Future Prospects.Biosensors · 2024Review
- Compositional assessment of bone by Raman spectroscopy.The Analyst · 2021Review
- Article
- Applications of Vibrational Spectroscopy for Analysis of Connective Tissues.Molecules (Basel, Switzerland) · 2021Review
- Spatially offset Raman spectroscopy for biomedical applications.Chemical Society reviews · 2021Review
- Perspective on optical imaging for functional assessment in musculoskeletal extremity trauma surgery.Journal of biomedical optics · 2020Article
- Accelerated Stimulated Raman Projection Tomography by Sparse Reconstruction From Sparse-View Data.IEEE transactions on bio-medical engineering · 2020Article
- Tissue Phantoms for Biomedical Applications in Raman Spectroscopy: A Review.Biomedical engineering and computational biology · 2020Review
- Spatially Offset and Transmission Raman Spectroscopy for Determination of Depth of Inclusion in Turbid Matrix.Analytical chemistry · 2019Article
- Assessing matrix quality by Raman spectroscopy helps predict fracture toughness of human cortical bone.Scientific reports · 2019Article
- Photoacoustic imaging in the second near-infrared window: a review.Journal of biomedical optics · 2019Review
- Non-invasiveTheranostics · 2019Article
- Raman Spectroscopy: Guiding Light for the Extracellular Matrix.Frontiers in bioengineering and biotechnology · 2019Review
- Optical and x-ray technology synergies enabling diagnostic and therapeutic applications in medicine.Journal of biomedical optics · 2018Review
- Assessing glycation-mediated changes in human cortical bone with Raman spectroscopy.Journal of biophotonics · 2018Article
- A Novel Multiscale Mathematical Model for Building Bone Substitute Materials for Children.Materials (Basel, Switzerland) · 2018Article
- Label-free Raman spectroscopy provides early determination and precise localization of breast cancer-colonized bone alterations.Chemical science · 2018Article
- Applying Full Spectrum Analysis to a Raman Spectroscopic Assessment of Fracture Toughness of Human Cortical Bone.Applied spectroscopy · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Combining diffuse optical tomography methods with Raman spectroscopy of tissue provides the ability for in vivo measurements of chemical and molecular characteristics, which have the potential for being useful in diagnostic imaging. In this study a system for Raman tomography was developed and tested. A third generation microCT coupled system was developed to combine 10 detection fibers and 5 excitation fibers with laser line filtering and a Cytop reference signal. Phantom measurements of hydroxyapatite concentrations from 50 to 300 mg/ml had a linear response. Fiber placement and experiment design was optimized using cadaver animals with live animal measurements acquired to validate the systems capabilities. Promising results from the initial animal experiments presented here, pave the way for a study of longitudinal measurements during fracture healing and the scaling of the Raman tomography system towards human measurements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.