Evidence map›Paper›PMID 25798236›Full record

ArticleBiomedical reports2015

Roles of Rheb(S16H) in substantia nigra pars compacta dopaminergic neurons

Min-Tae Jeon, Sang Ryong Kim

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Min-Tae JeonSchool of Life Sciences, Kyungpook National University, Daegu 700-842, Republic of Korea ; BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 700-842, Republic of Korea.
Sang Ryong KimSchool of Life Sciences, Kyungpook National University, Daegu 700-842, Republic of Korea ; BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 700-842, Republic of Korea ; Institute of Life Science and Biotechnology, Kyungpook National University, Daegu 702-701, Republic of Korea ; Brain Science and Engineering Institute, Kyungpook National University, Daegu 700-842, Republic of Korea.
Kyungpook National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although there are ongoing intensive research efforts, no effective pharmacological therapies for Parkinson's disease (PD) have been developed thus far. However, with the development of efficient gene delivery systems, gene therapy for PD has become a focus of research and increasing evidence suggests that continuous production of neurotrophic factors play a significant role in the functional restoration of the nigrostriatal dopaminergic (DA) system. Our recent study reported that the transduction of DA neurons with ras homolog enriched in brain, which has an S16H mutation [Rheb(S16H)], protected the nigrostriatal DA projection in a neurotoxin model of PD

Indexed as

brain-derived neurotrophic factorglial cell line-derived neurotrophic factorneuroprotectionParkinson's diseaseRheb(S16H)

Identifiers

PMID25798236
PMCPMC4360870
OpenAlexW2026151445

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.