ArticleBoneKEy reports2015
Exercise prevents β-aminopropionitrile-induced morphological changes to type I collagen in murine bone.
Article in BoneKEy reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Beyond bone volume: Understanding tissue-level quality in healing of maxillary vs. femoral defects.Acta biomaterialia · 2024Article
- Involvement of lysyl oxidase in the pathogenesis of arterial stiffness in chronic kidney disease.American journal of physiology. Renal physiology · 2023Article
- Collagen cross-link profiles and mineral are different between the mandible and femur with site specific response to perturbed collagen.Bone reports · 2022Article
- Moderate aerobic exercise prevents matrix degradation and death in a mouse model of aortic dissection and aneurysm.American journal of physiology. Heart and circulatory physiology · 2021Article
- Substrate Strain Mitigates Effects of β-Aminopropionitrile-Induced Reduction in Enzymatic Crosslinking.Calcified tissue international · 2019Article
- Advancements in composition and structural characterization of bone to inform mechanical outcomes and modelling.Current opinion in biomedical engineering · 2019Article
- Treadmill running and targeted tibial loading differentially improve bone mass in mice.Bone reports · 2019Article
- Strontium Oxide Deposited onto a Load-Bearable and Porous Titanium Matrix as Dynamic and High-Surface-Contact-Area Catalysis for Transesterification.Nanomaterials (Basel, Switzerland) · 2018Article
- Vibrational spectroscopic techniques to assess bone quality.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Review
- Differences in sensitivity to microstructure between cyclic- and impact-based microindentation of human cortical bone.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
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- Structural and Mechanical Improvements to Bone Are Strain Dependent with Axial Compression of the Tibia in Female C57BL/6 Mice.PloS one · 2015Article
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Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study evaluated the effects of reduced enzymatic crosslinking, exercise and the ability of exercise to prevent the deleterious impact of reduced crosslinking on collagen D-spacing. Eight-week-old female mice were divided into four weight-matched groups receiving daily injections of either phosphate-buffered saline (PBS) or 300 mg kg(-1) β-aminopropionitrile (BAPN) while undergoing normal cage activity (Sed) or 30 min per day of treadmill exercise (Ex) for 21 consecutive days. BAPN caused a downward shift in the D-spacing distribution in Sed BAPN compared with Sed PBS (P<0.001) but not in Ex BAPN (P=0.429), indicating that exercise can prevent changes in collagen morphology caused by BAPN. Exercise had no effect on D-spacing in PBS control mice (P=0.726), which suggests that exercise-induced increases in lysyl oxidase may be a possible mechanism for preventing BAPN-induced changes in D-spacing. The D-spacing changes were accompanied by an increase in mineral crystallinity/maturity due to the main effect of BAPN (P=0.016). However, no changes in nanoindentation, reference point indentation or other Raman spectroscopy parameters were observed. The ability of exercise to rescue BAPN-driven changes in collagen morphology necessitates further research into the use of mechanical stimulation as a preventative therapy for collagen-based diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.