Evidence map›Paper›PMID 25798149›Full record

ArticleThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

Hepatitis C virus seroconversion among HIV-positive men who have sex with men with no history of injection drug use: Results from a clinical HIV cohort.

Ann N Burchell, Sandra L Gardner, Tony Mazzulli, Michael Manno, Janet Raboud, Vanessa G Allen, Ahmed M Bayoumi, Rupert Kaul, Frank McGee, Peggy Millson and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
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  13. Risk Factors for Hepatitis C Virus Reinfection After Sustained Virologic Response in Patients Coinfected With HIV.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017
    Article
  14. Article
  15. Article
  16. Hepatitis C in Canada and the importance of risk-based screening.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2016
    Article
  17. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 3 countries.

Ann N BurchellOntario HIV Treatment Network; ; Dalla Lana School of Public Health, University of Toronto;
Sandra L GardnerOntario HIV Treatment Network; ; Dalla Lana School of Public Health, University of Toronto;
Tony MazzulliPublic Health Laboratories, Public Health Ontario; ; Department of Microbiology, Mount Sinai Hospital; ; Department of Laboratory Medicine and Pathobiology, University of Toronto;
Michael MannoOntario HIV Treatment Network;
Janet RaboudDalla Lana School of Public Health, University of Toronto; ; Toronto General Research Institute, University Health Network;
Vanessa G AllenPublic Health Laboratories, Public Health Ontario;
Ahmed M BayoumiCentre for Research on Inner City Health, The Keenan Research Centre in the Li KaShing Knowledge Institute, St Michael's Hospital; ; Institute of Health Policy, Management and Evaluation, University of Toronto; ; Department of Medicine, University of Toronto;
Rupert KaulDepartment of Medicine, University of Toronto;
Frank McGeeAIDS Bureau, Ontario Ministry of Health and Long-Term Care;
Peggy MillsonDalla Lana School of Public Health, University of Toronto;
Robert S RemisDalla Lana School of Public Health, University of Toronto; ; Public Health Laboratories, Public Health Ontario;
Wendy WobeserHotel Dieu Hospital; ; Queen's University, Kingston;
Curtis CooperOttawa Hospital; ; University of Ottawa, Ottawa;
Sean B RourkeOntario HIV Treatment Network; ; Centre for Research on Inner City Health, The Keenan Research Centre in the Li KaShing Knowledge Institute, St Michael's Hospital; ; Department of Psychiatry, University of Toronto.
University of Toronto · CA3M (United States) · USOntario HIV Treatment Network · CAMinistry of Health and Long Term Care · CAOttawa Hospital · CAPublic Health Ontario · CAQueen's University · CASt. Michael's Hospital · CAToronto Public Health · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInternationally, there is a growing recognition that hepatitis C virus (HCV) may be sexually transmitted among HIV-positive men who have sex with men (MSM).

objectiveTo report the first Canadian estimate of HCV seroincidence in 2000 to 2010 and its risk factors among HIV-positive MSM with no known history of injection drug use.

methodsData from the Ontario HIV Treatment Network Cohort Study, an ongoing cohort of individuals in HIV care in Ontario, were analyzed. Data were obtained from medical charts, interviews and record linkage with the provincial public health laboratories. The analysis was restricted to 1534 MSM who did not report injection drug use and had undergone ≥2 HCV antibody tests, of which the first was negative (median 6.1 person-years [PY] of follow-up; sum 9987 PY).

resultsIn 2000 to 2010, 51 HCV seroconversions were observed, an overall incidence of 5.1 per 1000 PY (95% CI 3.9 to 6.7). Annual incidence varied from 1.6 to 8.9 per 1000 PY, with no statistical evidence of a temporal trend. Risk for seroconversion was elevated among men who had ever had syphilis (adjusted HR 2.5 [95% CI 1.1 to 5.5) and men who had acute syphilis infection in the previous 18 months (adjusted HR 2.8 [95% CI 1.0 to 7.9]). Risk was lower for men who had initiated antiretroviral treatment (adjusted HR 0.49 [95% CI 0.25 to 0.95]). There were no statistically significant effects of age, ethnicity, region, CD4 cell count or HIV viral load.

conclusionsThese findings suggest that periodic HCV rescreening may be appropriate in Ontario among HIV-positive MSM. Future research should seek evidence whether syphilis is simply a marker for high-risk sexual behaviour or networks, or whether it potentiates sexual HCV transmission among individuals with HIV.

Indexed as

Hepatitis C virusHIVIncidenceMen who have sex with menSyphilis

Identifiers

PMID25798149
PMCPMC4353264
OpenAlexW2211738470

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.