ReviewFrontiers in immunology2015
Exploring the risk factors for sudden infant deaths and their role in inflammatory responses to infection.
Review in Frontiers in immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Exploring the safety and efficacy of targeted temperature management amongst infants with out-of-hospital cardiac arrest due to apparent life threatening events.Resuscitation · 2016Trial
- Global trends, projections, and inequalities in neonatal sudden infant death syndrome mortality attributable to risk factors from 1990 to 2021.Translational pediatrics · 2026Article
- Review
- Hidden and Under-Recognized Causes of Sudden Unexpected Death in Infancy (SUDI): A Comprehensive Review of Autopsy Findings.Diagnostics (Basel, Switzerland) · 2026Review
- Global burden, inequalities, frontier dynamics, and risk factors of sudden infant death syndrome, 1990-2021: a systematic analysis from the global burden of disease study 2021.Translational pediatrics · 2025Article
- The vicious spiral in Sudden Infant Death Syndrome.Frontiers in pediatrics · 2025Review
- Rates of Sudden Unexpected Infant Death Before and During the COVID-19 Pandemic.JAMA network open · 2024Article
- Death from Failed Protection? An Evolutionary-Developmental Theory of Sudden Infant Death Syndrome.Human nature (Hawthorne, N.Y.) · 2024Review
- Pulmonary immune profiling of SIDS: impaired immune maturation and age-related cytokine imbalance.Pediatric research · 2023Article
- The Protective Effects of Iron Free Lactoferrin on Lipopolysaccharide-Induced Intestinal Inflammatory Injury via Modulating the NF-κB/PPAR Signaling Pathway.Foods (Basel, Switzerland) · 2022Article
- The Science (or Nonscience) of Research Into Sudden Infant Death Syndrome (SIDS).Frontiers in pediatrics · 2022Article
- Increased Platelet-Derived Growth Factor and Cytokine Levels in the Cerebrospinal Fluid of Patients of Sudden Unexpected Death with or without Viral Infection.Indian journal of pediatrics · 2021Article
- Nicotinic Receptors in the Brainstem Ascending Arousal System in SIDS With Analysis of Pre-natal Exposures to Maternal Smoking and Alcohol in High-Risk Populations of the Safe Passage Study.Frontiers in neurology · 2021Article
- Computational and Transcriptome Analyses Revealed Preferential Induction of Chemotaxis and Lipid Synthesis by SARS-CoV-2.Biology · 2020Article
- Evaluation of the presence and distribution of leptomeningeal inflammation in SIDS/SUDI cases and comparison with a hospital-based cohort.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
- Mechanisms underlying a critical period of respiratory development in the rat.Respiratory physiology & neurobiology · 2019Review
- Evidence for an association of interferon gene variants with sudden infant death syndrome.International journal of legal medicine · 2019Article
- A Retrospective Forensic Review of Unexpected Infectious Deaths.Open forum infectious diseases · 2019Article
- Is ambient air pollution associated with onset of sudden infant death syndrome: a case-crossover study in the UK.BMJ open · 2018Article
- Infection: the neglected paradigm in SIDS research.Archives of disease in childhood · 2017Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The risk factors for sudden infant death syndrome (SIDS) parallel those associated with susceptibility to or severity of infectious diseases. There is no evidence that a single infectious agent is associated with SIDS; the common thread appears to be induction of inflammatory responses to infections. In this review, interactions between genetic and environmental risk factors for SIDS are assessed in relation to the hypothesis that many infant deaths result from dysregulation of inflammatory responses to "minor" infections. Risk factors are assessed in relation to three important stages of infection: (1) bacterial colonization (frequency or density); (2) induction of temperature-dependent toxins; (3) induction or control of inflammatory responses. In this article, we review the interactions among risk factors for SIDS for their effects on induction or control of inflammatory responses. The risk factors studied are genetic factors (sex, cytokine gene polymorphisms among ethnic groups at high or low risk of SIDS); developmental stage (changes in cortisol and testosterone levels associated with 2- to 4-month age range); environmental factors (virus infection, exposure to cigarette smoke). These interactions help to explain differences in the incidences of SIDS observed between ethnic groups prior to public health campaigns to reduce these infant deaths.
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