ArticleFrontiers in systems neuroscience2015
The effect of immature adult-born dentate granule cells on hyponeophagial behavior is related to their roles in learning and memory.
Article in Frontiers in systems neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Inhibition of stress resilience and adult hippocampal neurogenesis by platelet-derived LPA16:0 in anxiety.Nature communications · 2026Article
- Anxiety and hippocampal neuronal activity: Relationship and potential mechanisms.Cognitive, affective & behavioral neuroscience · 2022Review
- Alcohol and Cocaine Combined Substance Use on Adult Hypothalamic Neural Stem Cells and Neurogenesis.Brain plasticity (Amsterdam, Netherlands) · 2020Review
- Regulation of embryonic and adult neurogenesis by Ars2.Development (Cambridge, England) · 2020Article
- The role of adult hippocampal neurogenesis in brain health and disease.Molecular psychiatry · 2019Review
- JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche.Molecular psychiatry · 2018Article
- A critical period for antidepressant-induced acceleration of neuronal maturation in adult dentate gyrus.Translational psychiatry · 2017Article
- Neurogenesis Inhibition Prevents Enriched Environment to Prolong and Strengthen Social Recognition Memory, But Not to Increase BDNF Expression.Molecular neurobiology · 2017Article
- Depletion of adult neurogenesis using the chemotherapy drug temozolomide in mice induces behavioural and biological changes relevant to depression.Translational psychiatry · 2017Article
- Lasting Adaptations in Social Behavior Produced by Social Disruption and Inhibition of Adult Neurogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
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2 authors.
Funding
Abstract
The neurogenesis hypothesis of depression is based on the correlation between the rate of adult hippocampal neurogenesis and the affective status of rodents. However, studies investigating the role of neurogenesis in the causation of mood regulation have reported inconsistent results. Here, we explored whether the affective state can be affected differentially by adult-born neurons with distinctive physiological characteristics at different maturation stages. We revealed that reducing the immature newborn neuron population had no effect on anxiety- or depression-like behaviors in an array of tests; however, it enhanced hyponeophagia in a novelty suppressed feeding test, but only when the novel environment was drastically different from the home cage. We further demonstrated that reducing the immature newborn neuron population led to delayed habituation to a novel environment and impaired contextual learning. Hence, rather than being directly involved in mood regulation, our studies raise the possibility that adult neurogenesis may influence hyponeophagia through its role in mnemonic processing.
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