Evidence map›Paper›PMID 25798075›Full record

ArticlePopulation health metrics2015

Erosion of the healthy soldier effect in veterans of US military service in Iraq and Afghanistan.

Mary J Bollinger, Susanne Schmidt, Jacqueline A Pugh, Helen M Parsons, Laurel A Copeland, Mary Jo Pugh

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Population health metrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06429657 (Ketamine for Sedation in Severe Traumatic Brain Injury), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06429657 phase4suspendednot on this mapstarted 2024, after this paper: background citation

Ketamine for Sedation in Severe Traumatic Brain Injury

TypeinterventionalSponsorHenry M. Jackson Foundation for the Advancement of Military MedicineRan2024 to 2027Enrolled50ConditionsSevere Traumatic Brain Injury, Intracranial Hypertension, Intracranial Hemorrhage, HypertensiveArmsKetamine with propofol, Standard of Care propofol, fentanyl, dexmedetomidine, morphine, hydromorphone, midazolam, or lorazepam
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Thyroid-Stimulating Hormone, Thyroid Hormones, and Risk of Papillary Thyroid Cancer: A Nested Case-Control Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Mary J BollingerSouth Texas Veterans Health Care System, 7400 Merton Minter Blvd, San Antonio, Texas USA ; Department of Medicine, Division of Hospital Medicine, University of Texas Health Science Center, San Antonio, Texas USA.
Susanne SchmidtDepartment of Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio, Texas USA.
Jacqueline A PughSouth Texas Veterans Health Care System, 7400 Merton Minter Blvd, San Antonio, Texas USA ; Department of Medicine, Division of Hospital Medicine, University of Texas Health Science Center, San Antonio, Texas USA.
Helen M ParsonsDepartment of Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio, Texas USA.
Laurel A CopelandCentral Texas Veterans Health Care System, Department of Veterans Affairs, 1901 Veterans Memorial Drive, Temple, Texas 76504 USA ; Center for Applied Health Research, Baylor Scott & White Health, 2102 Birdcreek Drive, Temple, Texas 76502 USA.
Mary Jo PughSouth Texas Veterans Health Care System, 7400 Merton Minter Blvd, San Antonio, Texas USA ; Department of Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio, Texas USA.
The University of Texas Health Science Center at San Antonio · USSouth Texas Veterans Health Care System · USCentral Texas Veterans Health Care System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis research explores the healthy soldier effect (HSE) - a lower mortality risk among veterans relative to the general population-in United States (US) veterans deployed in support of operations in Iraq and Afghanistan (OEF/OIF/OND). While a HSE has been affirmed in other OEF/OIF/OND populations, US veterans of OEF/OIF/OND have not been systematically studied.

methodsUsing US Department of Veterans Affairs (VA) administrative data, we identified veterans who (1) had been deployed in support of OEF/OIF/OND between 2002 and 2011 and (2) were enrolled in the VA health care system. We divided the VA population into VA health care utilizers and non-utilizers. We obtained Department of Defense (DOD) administrative data on the OEF/OIF/OND population and obtained VA and DOD mortality data excluding combat deaths from the analyses. Indirect standardization was used to compare VA and DOD cohorts to the US population using total population at risk to compute the Standardized Mortality Ratio (SMR). A directly standardized relative risk (DSRR) was calculated to enable comparisons between cohorts. To compare VA enrollee mortality on military specific characteristics, we used a DOD population standard.

resultsThe overall VA SMR of 2.8 (95% Confidence Interval [CI] 2.8-2.9), VA utilizer SMR of 3.2 (95% CI 3.1-3.3), VA non-utilizer SMR of 0.9 (95% CI 0.8-1.1), and DOD SMR of 1.5 (95% CI 1.4-1.5) provide no evidence of a HSE in any cohort relative to the US standard population. Relative to DOD, both the total VA population SMR of 2.1 (95% CI 2.0-2.2) and the SMR for VA utilizers of 2.3 (95% CI 2.3-2.4) indicate mortality twice what would be expected given DOD mortality rates. In contrast, the VA enrollees who had not used clinical services had 40% lower than expected mortality relative to DOD.

conclusionsNo support was found for the HSE among US veterans of OEF/OIF/OND. These findings may be attributable to a number of factors including post-deployment risk-taking behavior, an abbreviated follow up period, and the nature of the OEF/OIF/OND conflict.

Indexed as

Healthy soldier effectMortalityVeterans/statistics & numerical data

Identifiers

PMID25798075
PMCPMC4367975
OpenAlexW2105697361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.