ArticleInternational journal of biological sciences2015
Tetratricopeptide repeat domain 9A negatively regulates estrogen receptor alpha activity.
Article in International journal of biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Shared Genetics of Kidney Function Traits and Bladder Cancer: A Genome-Wide Cross-Trait Analysis.Cancer medicine · 2026Article
- Central amygdalaNeurobiology of stress · 2026Article
- Differential Dynamics and Roles of FKBP51 Isoforms and Their Implications for Targeted Therapies.International journal of molecular sciences · 2024Article
- [A pan-cancer analysis of TTC9A expression level and its correlation with prognosis and immune microenvironment].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- FKBP5 inhibitors modulate alcohol drinking and trauma-related behaviors in a model of comorbid post-traumatic stress and alcohol use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Knockdown of TTC9 inhibits the proliferation, migration and invasion, but induces the apoptosis of lung adenocarcinoma cells.Heliyon · 2022Article
- Tetratricopeptide repeat domain 9A knockout induces social anxiety and impairs offense behaviors in female mice.Iranian journal of basic medical sciences · 2022Article
- Sex Differences in Depression Caused by Early Life Stress and Related Mechanisms.Frontiers in neuroscience · 2022Review
- Genomic factors underlying sex differences in trauma-related disorders.Neurobiology of stress · 2021Article
- Article
- Sex differences in the effect of the FKBP5 inhibitor SAFit2 on anxiety and stress-induced reinstatement following cocaine self-administration.Neurobiology of stress · 2020Article
- DNA methylation biomarkers prospectively predict both antenatal and postpartum depression.Psychiatry research · 2020Article
- Article
- FKBP51 regulates cell motility and invasion via RhoA signaling.Cancer science · 2017Article
- The Effect of Estradiol on the Growth Plate Chondrocytes of Limb and Spine from Postnatal MiceInternational journal of biological sciences · 2017Article
- Tetratricopeptide repeat domain 9A modulates anxiety-like behavior in female mice.Scientific reports · 2016Article
- Replication of Epigenetic Postpartum Depression Biomarkers and Variation with Hormone Levels.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Gene-Stress-Epigenetic Regulation of FKBP5: Clinical and Translational Implications.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Tetratricopeptide repeat domain 9A (TTC9A) is a target gene of estrogen and progesterone. It is over-expressed in breast cancer. However, little is known about the physiological function of TTC9A. The objectives of this study were to establish a Ttc9a knockout mouse model and to study the consequence of Ttc9a gene inactivation. The Ttc9a targeting vector was generated by replacing the Ttc9a exon 1 with a neomycin cassette. The mice homozygous for Ttc9a exon 1 deletion appear to grow normally and are fertile. However, further characterization of the female mice revealed that Ttc9a deficiency is associated with greater body weight, bigger thymus and better mammary development in post-pubertal mice. Furthermore, Ttc9a deficient mammary gland was more responsive to estrogen treatment with greater mammary ductal lengthening, ductal branching and estrogen target gene induction. Since Ttc9a is induced by estrogen in estrogen target tissues, these results suggest that Ttc9a is a negative regulator of estrogen function through a negative feedback mechanism. This is supported by in vitro evidence that TTC9A over-expression attenuated ERα activity in MCF-7 cells. Although TTC9A does not bind to ERα or its chaperone protein Hsp90 directly, TTC9A strongly interacts with FKBP38 and FKBP51, both of which interact with ERα and Hsp90 and modulate ERα activity. It is plausible therefore that TTC9A negatively regulates ERα activity through interacting with co-chaperone proteins such as FKBP38 and FKBP51.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.