Evidence map›Paper›PMID 25798032›Full record

ArticleCurrent trends in endocrinology

Familiar and novel reproductive endocrine disruptors: xenoestrogens, dioxins and nanoparticles.

R J Hutz, M J Carvan, J K Larson, Q Liu, R V Stelzer, T C King-Heiden, M G Baldridge, N Shahnoor, K Julien

Open access · greenAbstract read
In one paragraph

Article in Current trends in endocrinology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Epigenetic Regulations of AhR in the Aspect of Immunomodulation.International journal of molecular sciences · 2020
    Review
  6. Article
  7. Article
  8. Aryl Hydrocarbon Receptor and Stem Cells.Stem cells international · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

R J HutzDepartment of Biological Sciences, University of Wisconsin-Milwaukee (UWM), Milwaukee, WI, USA ; School of Freshwater Sciences, UWM, Milwaukee, WI, USA ; Departments of Obstetrics and Gynecology, Physiology, and Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA ; Wisconsin National Primate Research Center (WNPRC), University of Wisconsin, Madison, WI, USA.
M J CarvanDepartment of Biological Sciences, University of Wisconsin-Milwaukee (UWM), Milwaukee, WI, USA ; School of Freshwater Sciences, UWM, Milwaukee, WI, USA.
J K LarsonDepartment of Biological Sciences, University of Wisconsin-Milwaukee (UWM), Milwaukee, WI, USA.
Q LiuDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
R V StelzerBiological Sciences Program, Bryant and Stratton College, Milwaukee, WI, USA.
T C King-HeidenDepartment of Biology, University of Wisconsin-La Crosse, La Crosse, WI, USA.
M G BaldridgeDepartment of Health and Medicine, Carroll University, Waukesha, WI, USA.
N ShahnoorDepartment of Natural Sciences, Milwaukee Area Technical College, Milwaukee, WI, USA ; Neuromuscular Laboratory, Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
K JulienDepartment of Internal Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Carroll University · USMedical College of Wisconsin · USStanford University · USUniversity of Wisconsin–La Crosse · USUniversity of Wisconsin–Milwaukee · US

Funding

ZOLEDRONATE PREVENTS BONE LOSS IN OVARIECTOMIZED RHESUS MONKEYSP51RR000167 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI WATKINS, DAVID I · 1985 to 2011
$106.7M
Pilot Project ProgramP30ES004184 · NIEHS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI PETERING, DAVID HAROLD · 1987 to 2015
$11.8M
Modulation by dioxin of ovarian estrogen synthesisR15ES011569 · NIEHS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI HUTZ, REINHOLD JOSEF · 2002 to 2002
$141k
NCRR NIH HHS P51 RR000167NIEHS NIH HHS P30 ES004184NIEHS NIH HHS R15 ES011569
6 · The paper itself

Abstract

Environmental contaminants are known to exert endocrine-disrupting effects on the reproductive axis of animals. Many of these molecules can affect steroid biosynthesis or estrogen-receptor signaling by behaving as estrogen-like molecules ("xenoestrogens"), or by exerting estrogenmodulatory effects. Exposure to some compounds has been correlated with the skewing of sex ratios in aquatic species, feminization and demasculinization of male animals, declines in human sperm counts, and overall diminution in fertility of birds, fish, and mammals. We herein devote space to several classes of endocrine-disrupting compounds (EDCs), including estrogenic substances such as bisphenol A (BPA), molecules that can behave at times anti-estrogenically while activating the aromatic hydrocarbon receptor (AHR), such as dioxins (a known human carcinogen), and novel, ubiquitous molecules such as nanoparticles, particularly gold nanoparticles (GNPs), that appear to alter the sexsteroid biosynthetic pathway.

Indexed as

dioxinendocrine disruptorfertilitynanoparticleovaryxenoestrogen

Identifiers

PMID25798032
PMCPMC4364387
OpenAlexW2402227203

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.