ArticleScientific reports2015
Integrating clinical indexes into four-diagnostic information contributes to the Traditional Chinese Medicine (TCM) syndrome diagnosis of chronic hepatitis B.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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27 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Health-related quality-of-life among patients with premature ovarian insufficiency: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Pooled it
- Comparative Proteomic Profiling and Biomarker Identification of Traditional Chinese Medicine-Based HIV/AIDS Syndromes.Scientific reports · 2018Trial
- Serum Biomarker Identification of Damp-Heat Pattern in Patients with Chronic Liver Diseases.Chinese journal of integrative medicine · 2026Article
- Multi-omics-based study on the biological characteristics of kidney renal deficiency and blood stasis in ankylosing spondylitis.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Article
- Traditional Chinese Medicine in Cushing's Syndrome: A Narrative Review of Pathophysiology and Potential Therapeutic Effects.OncoTargets and therapy · 2026Review
- Exploring the potential of acupuncture practice education using artificial intelligence.Integrative medicine research · 2025Review
- Chinmedomics: a potent tool for the evaluation of traditional Chinese medicine efficacy and identification of its active components.Chinese medicine · 2024Review
- HHO optimized support vector machine classifier for traditional Chinese medicine syndrome differentiation of diabetic retinopathy.International journal of ophthalmology · 2024Article
- Personalized checkpoint acupuncture can reduce postoperative pain after abdominal surgery-a STRICTA-conform pilot study.Langenbeck's archives of surgery · 2023Article
- From the West to the East: an evidence-based educational reform for modern medical students in traditional Chinese medicine learning.Frontiers in medicine · 2023Article
- Distinct common signatures of gut microbiota associated with damp-heat syndrome in patients with different chronic liver diseases.Frontiers in pharmacology · 2022Article
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- Research of insomnia on traditional Chinese medicine diagnosis and treatment based on machine learning.Chinese medicine · 2021Article
- Detection Method and System of the Human Body Characteristic Index Based on TCM.Journal of healthcare engineering · 2021Article
- A New Method for Syndrome Classification of Non-Small-Cell Lung Cancer Based on Data of Tongue and Pulse with Machine Learning.BioMed research international · 2021Article
- Study on the Expression Differences and the Correlation with H2BE Gene of Th Related Cytokines in SSDHS and LDSDS TCM-Syndromes of CHB Patients.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Article
- A Microcosmic Syndrome Differentiation Model for Metabolic Syndrome with Multilabel Learning.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Biological Differentiation of Dampness-Heat Syndromes in Chronic Hepatitis B: From Comparative MicroRNA Microarray Profiling to Biomarker Identification.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Factor and Cluster Analysis for TCM Syndromes of Real-World Metabolic Syndrome at Different Age Stage.Evidence-based complementary and alternative medicine : eCAM · 2020Article
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Authors and funding
12 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Traditional Chinese Medicine (TCM) treatment has been commonly used to treat Chronic Hepatitis B (CHB) in Asian countries based on TCM syndrome diagnosis, also called "ZHENG". The syndrome is identified through the four-diagnostic methods, with certain degree of subjectivity and ambiguity from individual doctors. Normally those CHB patients also receive series of parameters from modern clinical examination, while they are routinely believed to be unrelated with the TCM syndrome diagnosis. In this study, we investigated whether these biomedical indexes in modern medicine could be beneficial to TCM syndrome diagnostics in an integrative way. Based on 634 patient samples from health controls and three subtypes of CHB syndromes, a two-view based hierarchical classification model was tested for TCM syndromes prediction based on totally 222 parameters integrated from both TCM practice and modern clinical tests. The results indicated that the performance of syndrome classification based on a proper integration of TCM and modern clinical indexes was significantly higher than those based on one view of parameters only. Furthermore, those indexes correlated with CHB syndrome diagnosis were successfully identified for CM indexes and biochemical indexes respectively, where potential associations between them were hinted to the MAPK signaling pathway.
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