ArticleBiochemical and biophysical research communications2015
Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: A potential model for study of defective copper regulation in metabolic liver disease.
Article in Biochemical and biophysical research communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Copper and hepatic lipid dysregulation: Mechanisms and implications.World journal of hepatology · 2025Review
- Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex.Cell reports · 2022Article
- Full-length ATP7B reconstituted through proteinMolecular therapy. Methods & clinical development · 2022Article
- Association of plasma trace element levels with neovascular age-related macular degeneration.Experimental eye research · 2020Article
- Copper Ionophores as Novel Antiobesity Therapeutics.Molecules (Basel, Switzerland) · 2020Article
- Copper Transport and Disease: What Can We Learn from Organoids?Annual review of nutrition · 2019Review
- Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Plasma metals as potential biomarkers in dementia: a case-control study in patients with sporadic Alzheimer's disease.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2018Article
- Micronutrients in Nonalcoholic Fatty Liver Disease Pathogenesis.Cellular and molecular gastroenterology and hepatology · 2018Review
- Low Hepatic Tissue Copper in Pediatric Nonalcoholic Fatty Liver Disease.Journal of pediatric gastroenterology and nutrition · 2017Article
- Thiol oxidase ability of copper ion is specifically retained upon chelation by aldose reductase.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2017Article
- Review
- In vivo bioluminescence imaging reveals copper deficiency in a murine model of nonalcoholic fatty liver disease.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer's disease: metabolic basis for dementia.Scientific reports · 2016Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Ob/ob mice provide an animal model for non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH) in patients with obesity and type-2 diabetes. Low liver copper has been linked to hepatic lipid build-up (steatosis) in animals with systemic copper deficiency caused by low-copper diets. However, hepatic copper status in patients with NAFLD or NASH is uncertain, and a validated animal model useful for the study of hepatic copper regulation in common forms of metabolic liver disease is lacking. Here, we report parallel measurements of essential metal levels in whole-liver tissue and defatted-dried liver tissue from ob/ob and non-obese control mice. Measurements in whole-liver tissue from ob/ob mice at an age when they have developed NAFLD/NASH, provide compelling evidence for factitious lowering of copper and all other essential metals by steatosis, and so cannot be used to study hepatic metal regulation in this model. By marked contrast, metal measurements in defatted-dried liver samples reveal that most essential metals were actually normal and indicate specific lowering of copper in ob/ob mice, consistent with hepatic copper deficiency. Thus ob/ob mice can provide a model useful for the study of copper regulation in NAFLD and NASH, provided levels are measured in defatted-dried liver tissue.
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