ArticleDevelopment and psychopathology2016
Susceptibility effects of GABA receptor subunit alpha-2 (GABRA2) variants and parental monitoring on externalizing behavior trajectories: Risk and protection conveyed by the minor allele.
Article in Development and psychopathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetics of child aggression, a systematic review.Translational psychiatry · 2024Pooled it
- Combined effects of HCRTR1/2 gene variants and non-genetic factors on sleep-wake transition and hemodynamic stability during propofol, dexmedetomidine, and remifentanil anesthesia.Pharmacological reports : PR · 2025Article
- Genetic interactions with stressful environments in depression and addiction.BJPsych advances · 2021Article
- The Effects of Gene Variations ofPharmacogenomics and personalized medicine · 2021Article
- Time-varying Effects of GABRG1 and Maladaptive Peer Behavior on Externalizing Behavior from Childhood to Adulthood: Testing Gene × Environment × Development Effects.Journal of youth and adolescence · 2020Article
- Psychometric Properties of a Comprehensive Parenting Practice Measure for Parents of Adolescents.Child & adolescent social work journal : C & A · 2020Article
- When is Parental Monitoring Effective? A Person-centered Analysis of the Role of Autonomy-supportive and Psychologically Controlling Parenting in Referred and Non-referred Adolescents.Journal of youth and adolescence · 2020Article
- The Impact of Genes on Adolescent Substance Use: A Developmental Perspective.Current addiction reports · 2019Article
- Do parenting behaviors modify the way sensation seeking influences antisocial behaviors?Journal of child psychology and psychiatry, and allied disciplines · 2019Article
- Developmental Change in Adolescent Delinquency: Modeling Time-Varying Effects of a Preventative Intervention and GABRA2 Halpotype Linked to Alcohol Use.Journal of youth and adolescence · 2019Article
- Parenting, culture, and the development of externalizing behaviors from age 7 to 14 in nine countries.Development and psychopathology · 2018Article
- Assessment of culture and environment in the Adolescent Brain and Cognitive Development Study: Rationale, description of measures, and early data.Developmental cognitive neuroscience · 2018Review
- Pathways to Youth Behavior: The Role of Genetic, Neural, and Behavioral Markers.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2018Article
- Developmental Patterns of Child Emotion Dysregulation as Predicted by Serotonin Transporter Genotype and Parenting.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2018Article
- PROSPER Intervention Effects on Adolescents' Alcohol Misuse Vary by GABRA2 Genotype and Age.Prevention science : the official journal of the Society for Prevention Research · 2018Article
- Beyond risk: Prospective effects of GABA Receptor Subunit Alpha-2 (GABRA2) × Positive Peer Involvement on adolescent behavior.Development and psychopathology · 2017Article
- Longitudinal Associations Between Parental Monitoring Discrepancy and Delinquency: An Application of the Latent Congruency Model.Journal of youth and adolescence · 2016Article
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5 authors.
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Abstract
Understanding factors increasing susceptibility to social contexts and predicting psychopathology can help identify targets for prevention. Persistently high externalizing behavior in adolescence is predictive of psychopathology in adulthood. Parental monitoring predicts low externalizing behavior, yet youth likely vary in the degree to which they are affected by parents. Genetic variants of GABA receptor subunit alpha-2 (GABRA2) may increase susceptibility to parental monitoring, thus impacting externalizing trajectories. We had several objectives: (a) to determine whether GABRA2 (rs279827, rs279826, rs279858) moderates the relationship between a component of parental monitoring, parental knowledge, and externalizing trajectories; (b) to test the form of this interaction to assess whether GABRA2 variants reflect risk (diathesis-stress) or susceptibility (differential susceptibility) factors; and (c) to clarify GABRA2 associations on the development of problem behavior. This prospective study (N = 504) identified three externalizing trajectory classes (i.e., low, decreasing, and high) across adolescence. A GABRA2 × Parental Monitoring effect on class membership was observed, such that A-carriers were largely unaffected by parental monitoring, whereas class membership for those with the GG genotype was affected by parental monitoring. Findings support differential susceptibility in GABRA2.
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