Evidence map›Paper›PMID 25797401›Full record

ArticlePsychiatry research2015

Cortical thickness and brain volumetric analysis in body dysmorphic disorder.

Sarah K Madsen, Alex Zai, Tara Pirnia, Donatello Arienzo, Liang Zhan, Teena D Moody, Paul M Thompson, Jamie D Feusner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Body dysmorphic disorder.Nature reviews. Disease primers · 2024
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sarah K MadsenImaging Genetics Center, Institute for Neuroimaging & Informatics, Department of Neurology, University of Southern California, Marina del Rey, CA, USA; Departments of Neurology, Psychiatry, Radiology, Pediatrics, Engineering, & Ophthalmology, University of Southern California, Los Angles, CA, USA. Electronic address: Sarah.Madsen@ini.usc.edu.
Alex ZaiDepartment of Neurology, University of California Los Angeles, Los Angeles, CA, USA.
Tara PirniaDepartment of Neurology, University of California Los Angeles, Los Angeles, CA, USA.
Donatello ArienzoSemel Institute for Neuroscience and Human Behavior, Department of Psychiatry, University of California Los Angeles, Los Angles, CA, USA.
Liang ZhanImaging Genetics Center, Institute for Neuroimaging & Informatics, Department of Neurology, University of Southern California, Marina del Rey, CA, USA; Department of Neurology, University of California Los Angeles, Los Angeles, CA, USA.
Teena D MoodySemel Institute for Neuroscience and Human Behavior, Department of Psychiatry, University of California Los Angeles, Los Angles, CA, USA.
Paul M ThompsonImaging Genetics Center, Institute for Neuroimaging & Informatics, Department of Neurology, University of Southern California, Marina del Rey, CA, USA; Departments of Neurology, Psychiatry, Radiology, Pediatrics, Engineering, & Ophthalmology, University of Southern California, Los Angles, CA, USA; Department of Neurology, University of California Los Angeles, Los Angeles, CA, USA; Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry, University of California Los Angeles, Los Angles, CA, USA.
Jamie D FeusnerSemel Institute for Neuroscience and Human Behavior, Department of Psychiatry, University of California Los Angeles, Los Angles, CA, USA.

Funding

TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Neurodevelopment and Imaging among HIV-infected Children from the PREDICT studyR01MH089722 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VALCOUR, VICTOR · 2010 to 2014
$3.1M
Searching for Endophenotypes of Bipolar DisorderR01MH085667 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SOARES, JAIR C · 2012 to 2016
$3.0M
Genetic Influences on Human Neuroanatomical ShapesR01MH094343 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2012 to 2016
$2.4M
Common and Distinct Phenotypes of Body Dysmorphic Disorder and Anorexia NervosaR01MH093535 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE · 2011 to 2015
$2.0M
Cognitive-Behavioral Therapy and Glutamate in Cingulate Gyrus in OCDR01MH085900 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE, O'NEILL, JOSEPH · 2011 to 2014
$1.8M
Empowering Personalized Medicine: Integrating Imaging, Genetics, and BiomarkersR01MH097268 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COPPOLA, GIOVANNI, THOMPSON, PAUL M · 2012 to 2014
$1.3M
Body Dysmorphic Disorder: clinical and neurobiological featuresK23MH079212 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE · 2007 to 2011
$752k
NIBIB NIH HHS P41 EB015922NIBIB NIH HHS U54 EB020403NIBIB NIH HHS U54EB020403NIMH NIH HHS K23 MH079212NIMH NIH HHS K23MH079212NIMH NIH HHS R01 MH085667NIMH NIH HHS R01 MH085900NIMH NIH HHS R01MH085900NIMH NIH HHS R01 MH089722NIMH NIH HHS R01 MH093535NIMH NIH HHS R01MH093535NIMH NIH HHS R01 MH094343NIMH NIH HHS R01 MH097268
6 · The paper itself

Abstract

Individuals with body dysmorphic disorder (BDD) suffer from preoccupations with perceived defects in physical appearance, causing severe distress and disability. Although BDD affects 1-2% of the population, the neurobiology is not understood. Discrepant results in previous volumetric studies may be due to small sample sizes, and no study has investigated cortical thickness in BDD. The current study is the largest neuroimaging analysis of BDD. Participants included 49 medication-free, right-handed individuals with DSM-IV BDD and 44 healthy controls matched by age, sex, and education. Using high-resolution T1-weighted magnetic resonance imaging, we computed vertex-wise gray matter (GM) thickness on the cortical surface and GM volume using voxel-based morphometry. We also computed volumes in cortical and subcortical regions of interest. In addition to group comparisons, we investigated associations with symptom severity, insight, and anxiety within the BDD group. In BDD, greater anxiety was significantly associated with thinner GM in the left superior temporal cortex and greater GM volume in the right caudate nucleus. There were no significant differences in cortical thickness, GM volume, or volumes in regions of interest between BDD and control subjects. Subtle associations with clinical symptoms may characterize brain morphometric patterns in BDD, rather than large group differences in brain structure.

Indexed as

AdolescentAdultBody Dysmorphic DisordersBrainFemaleGray MatterHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeuroimagingOrgan SizeYoung AdultAnxietyCortical thicknessGray matterMRIVolumeVoxel-based morphometry

Identifiers

PMID25797401
PMCPMC4404218

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.