ArticleJournal of veterinary science2015
Rapamycin treatment during in vitro maturation of oocytes improves embryonic development after parthenogenesis and somatic cell nuclear transfer in pigs.
Article in Journal of veterinary science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Autophagy in ovary: protective roles, pathological consequences, and unresolved issues.Journal of ovarian research · 2025Review
- Rapamycin Increases the Development Competence of Yak (Animals : an open access journal from MDPI · 2025Article
- Article
- Rapamycin improves the quality and developmental competence of mice oocytes by promoting DNA damage repair during in vitro maturation.Reproductive biology and endocrinology : RB&E · 2022Article
- Mitochondria: emerging therapeutic strategies for oocyte rescue.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- Rapamycin improves the developmental competence of human oocytes by alleviating DNA damage during IVM.Human reproduction open · 2022Article
- Effects of electromagnetic waves on oocyte maturation and embryonic development in pigs.The Journal of reproduction and development · 2021Article
- Characterization of the effects of heat stress on autophagy induction in the pig oocyte.Reproductive biology and endocrinology : RB&E · 2021Article
- Contextualizing Autophagy during Gametogenesis and Preimplantation Embryonic Development.International journal of molecular sciences · 2021Review
- Beneficial Effects of Neurotrophin-4 Supplementation DuringFrontiers in veterinary science · 2021Article
- Effect of autophagy induction and cathepsin B inhibition on developmental competence of poor quality bovine oocytes.The Journal of reproduction and development · 2020Article
- The autophagic inducer and inhibitor display different activities on the meiotic and developmental competencies of porcine oocytes derived from small and medium follicles.The Journal of reproduction and development · 2019Article
- Autophagy in Ovarian Follicular Development and Atresia.International journal of biological sciences · 2019Review
- Autophagy is required for proper meiosis of porcine oocytes maturing in vitro.Scientific reports · 2018Article
- Role of autophagy in modulating post-maturation aging of mouse oocytes.Cell death & disease · 2018Article
- Choosing a culture medium for SCNT and iSCNT reconstructed embryos: from domestic to wildlife species.Journal of animal science and technology · 2017Review
- A novel role of Beclin-1, cytokinetic abscission.Cell cycle (Georgetown, Tex.) · 2016Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was conducted to investigate the effects of rapamycin treatment during in vitro maturation (IVM) on oocyte maturation and embryonic development after parthenogenetic activation (PA) and somatic cell nuclear transfer (SCNT) in pigs. Morphologically good (MGCOCs) and poor oocytes (MPCOCs) were untreated or treated with 1 nM rapamycin during 0-22 h, 22-42 h, or 0-42 h of IVM. Rapamycin had no significant effects on nuclear maturation and blastocyst formation after PA of MGCOCs. Blastocyst formation after PA was significantly increased by rapamycin treatment during 22-42 h and 0-42 h (46.6% and 46.5%, respectively) relative to the control (33.3%) and 0-22 h groups (38.6%) in MPCOCs. In SCNT, blastocyst formation tended to increase in MPCOCs treated with rapamycin during 0-42 h of IVM relative to untreated oocytes (20.3% vs. 14.3%, 0.05 < p < 0.1), while no improvement was observed in MGCOCs. Gene expression analysis revealed that transcript abundance of Beclin 1 and microtubule-associated protein 1 light chain 3 mRNAs was significantly increased in MPCOCs by rapamycin relative to the control. Our results demonstrated that autophagy induction by rapamycin during IVM improved developmental competence of oocytes derived from MPCOCs.
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