SynthesisJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2015
Cannabinoids for the Treatment of Chronic Non-Cancer Pain: An Updated Systematic Review of Randomized Controlled Trials.
Synthesis in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 97 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nabilone and THC/CBD for the Treatment of FBSS Refractory Pain
A Phase II, Randomized, Open-label, Double-blind, Two-center Study to Evaluate the Tolerability, Safety and Dose-finding of Oil Cannabis Preparation for Pain in Parkinson's Disease
Pilot Study Using Topical Cannabidiol (CBD) to Manage Osteoarthritic Knee Pain
Who cites it
97 citing papers in PubMed, 9 syntheses or guidelines pooled it, 194 citations in OpenAlex.
- Efficacy of cannabis-based medicine in the treatment of Tourette syndrome: a systematic review and meta-analysis.European journal of clinical pharmacology · 2024Pooled it
- Clinical Practice Guidelines for Cannabis and Cannabinoid-Based Medicines in the Management of Chronic Pain and Co-Occurring Conditions.Cannabis and cannabinoid research · 2024Pooled it
- Analgesic Effects of Cannabinoids for Chronic Non-cancer Pain: a Systematic Review and Meta-Analysis with Meta-Regression.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020Pooled it
- Pooled it
- Cannabis for pain in orthopedics: a systematic review focusing on study methodologyCanadian journal of surgery. Journal canadien de chirurgie · 2019Pooled it
- Effects of cannabinoid administration for pain: A meta-analysis and meta-regression.Experimental and clinical psychopharmacology · 2019Pooled it
- Systematic review of systematic reviews for medical cannabinoids: Pain, nausea and vomiting, spasticity, and harms.Canadian family physician Medecin de famille canadien · 2018Pooled it
- Pharmacologic management of chronic neuropathic pain: Review of the Canadian Pain Society consensus statement.Canadian family physician Medecin de famille canadien · 2017Pooled it
- Cannabinoids in Pain Management and Palliative Medicine.Deutsches Arzteblatt international · 2017Pooled it
- Does Cannabis-based Medicine Improve Pain and Sleep Quality in Patients With Traumatic Brachial Plexus Injuries? A Triple-blind, Crossover, Randomized Controlled Trial.Clinical orthopaedics and related research · 2025Trial
- Patterns and factors among oncology fellows recommending medical cannabis to adults with cancer.Journal of cannabis research · 2025Article
- Cannabidiol for Orofacial and Upper-Quarter Pain: A Systematic Evaluation of Therapeutic Potential.Journal of clinical medicine · 2025Review
- US State Recreational and Medical Cannabis Delivery Laws, 2024.American journal of public health · 2025Article
- Role of Cannabis in the Management of Chronic Non-Cancer Pain: A Narrative Review.Clinics and practice · 2025Review
- ATTITUDES AND PRACTICE PATTERNS OF CANADIAN PHYSIATRISTS REGARDING MEDICAL CANNABIS.Journal of rehabilitation medicine. Clinical communications · 2025Article
- Discontinuation rates and predictors of Medical Cannabis cessation for chronic musculoskeletal pain.PloS one · 2025Article
- Exploring Natural Analgesics for Chronic Pain Management: Cannabinoids and other Phytoconstituents.Current medicinal chemistry · 2025Review
- Clinical Benefits and Safety of Medical Cannabis Products: A Narrative Review on Natural Extracts.Pain and therapy · 2024Review
- Cutaneous Delivery and Biodistribution of Cannabidiol in Human Skin after Topical Application of Colloidal Formulations.Pharmaceutics · 2024Article
- The Effects of Nicotine and Cannabinoids on Cytokines.Current pharmaceutical design · 2024Review
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An updated systematic review of randomized controlled trials examining cannabinoids in the treatment of chronic non-cancer pain was conducted according to PRISMA guidelines for systematic reviews reporting on health care outcomes. Eleven trials published since our last review met inclusion criteria. The quality of the trials was excellent. Seven of the trials demonstrated a significant analgesic effect. Several trials also demonstrated improvement in secondary outcomes (e.g., sleep, muscle stiffness and spasticity). Adverse effects most frequently reported such as fatigue and dizziness were mild to moderate in severity and generally well tolerated. This review adds further support that currently available cannabinoids are safe, modestly effective analgesics that provide a reasonable therapeutic option in the management of chronic non-cancer pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.