ArticleThe Journal of membrane biology2015
Picosecond and Terahertz Perturbation of Interfacial Water and Electropermeabilization of Biological Membranes.
Article in The Journal of membrane biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Terahertz Modulation of Biomolecular Dynamics: Physical Mechanisms, Biological Implications, and Future Challenges.Research (Washington, D.C.) · 2026Review
- A new horizon for neuroscience: terahertz biotechnology in brain research.Neural regeneration research · 2025Article
- Advances in Terahertz Biophysics and Chemistry.Research (Washington, D.C.) · 2025Review
- Progress of the Impact of Terahertz Radiation on Ion Channel Kinetics in Neuronal Cells.Neuroscience bulletin · 2024Review
- Membrane-mediated modulation of mitochondrial physiology by terahertz waves.Biomedical optics express · 2024Article
- Calcium Imaging Characterize the Neurobiological Effect of Terahertz Radiation in Zebrafish Larvae.Sensors (Basel, Switzerland) · 2023Article
- High Frequency Electromagnetic Radiation Stimulates Neuronal Growth and Hippocampal Synaptic Transmission.Brain sciences · 2023Article
- Recent advances and research progress on microsystems and bioeffects of terahertz neuromodulation.Microsystems & nanoengineering · 2023Review
- All-atom molecular dynamics simulations of the combined effects of different phospholipids and cholesterol content on electroporation.RSC advances · 2022Article
- Continuous wave irradiation at 0.1 terahertz facilitates transmembrane transport of small molecules.iScience · 2022Article
- Disassembly of microtubules by intense terahertz pulses.Biomedical optics express · 2021Article
- The interplay of excitation and electroporation in nanosecond pulse stimulation.Bioelectrochemistry (Amsterdam, Netherlands) · 2020Review
- The Effect of KcsA Channel on Lipid Bilayer Electroporation Induced by Picosecond Pulse Trains.The Journal of membrane biology · 2020Article
- Terahertz Electric Field-Induced Membrane Electroporation by Molecular Dynamics Simulations.The Journal of membrane biology · 2018Article
- Monopole patch antenna for in vivo exposure to nanosecond pulsed electric fields.Medical & biological engineering & computing · 2017Article
- Electroporation by subnanosecond pulses.Biochemistry and biophysics reports · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Non-thermal probing and stimulation with subnanosecond electric pulses and terahertz electromagnetic radiation may lead to new, minimally invasive diagnostic and therapeutic procedures and to methods for remote monitoring and analysis of biological systems, including plants, animals, and humans. To effectively engineer these still-emerging tools, we need an understanding of the biophysical mechanisms underlying the responses that have been reported to these novel stimuli. We show here that subnanosecond (≤500 ps) electric pulses induce action potentials in neurons and cause calcium transients in neuroblastoma-glioma hybrid cells, and we report complementary molecular dynamics simulations of phospholipid bilayers in electric fields in which membrane permeabilization occurs in less than 1 ns. Water dipoles in the interior of these model membranes respond in less than 1 ps to permeabilizing electric potentials by aligning in the direction of the field, and they re-orient at terahertz frequencies to field reversals. The mechanism for subnanosecond lipid electropore formation is similar to that observed on longer time scales-energy-minimizing intrusions of interfacial water into the membrane interior and subsequent reorganization of the bilayer into hydrophilic, conductive structures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.