Evidence map›Paper›PMID 25796380›Full record

ArticleJournal of molecular neuroscience : MN2015

Buyang Huanwu Decoction (BYHWD) Enhances Angiogenic Effect of Mesenchymal Stem Cell by Upregulating VEGF Expression After Focal Cerebral Ischemia.

Junhong Yang, Feng Gao, Yunke Zhang, Ying Liu, Di Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 86 citations in OpenAlex.

  1. Review
  2. Review
  3. Exosomes promise better bone regeneration.Regenerative therapy · 2025
    Review
  4. Application of mesenchymal stem cells in ferroptosis-related diseases.Journal of molecular medicine (Berlin, Germany) · 2025
    Review
  5. Nanobiotechnologies for stroke treatment.Nanomedicine (London, England) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

Junhong YangThe First Department of Encephalopathy, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, China.
Feng GaoDepartment of Neuroimmunology, Henan Province Academy of Medical and Pharmaceutical, Zhengzhou University, Zhengzhou, 450052, China.
Yunke ZhangThe Second Affiliated Hospital of Henan University of Traditional Chinese Medicine, No. 6, Dongfeng Road, Jinshui District, Zhengzhou, 450002, China. yunkezhang@126.com.
Ying LiuDepartment of Rehabilitation, Zhengzhou Hospital of Traditional Chinese Medicine, Zhengzhou, 450007, China.
Di ZhangLuoyang Center Hospital, Luoyang, 471000, China.
First Affiliated Hospital of Henan University of Traditional Chinese Medicine · CNHenan University of Traditional Chinese Medicine · CNLuoyang Institute of Science and Technology · CNZhengzhou City Hospital · CNZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Buyang Huanwu decoction (BYHWD) has been used for centuries to treat paralysis and stroke. Previously, we have demonstrated that BYHWD combined with mesenchymal stem cell (MSC) transplantation attenuates ischemic injury partly by upregulating angiogenesis. However, the mechanisms of this drug for stroke treatment are not completely understood. Here, we aimed to clarify the mechanism of BYHWD on angiogenesis mediated by MSCs. Firstly, we verified microvessels with a size of 50-100 nm produced by either MSCs or MSCs treated by 500 μg/ml BYHWD. These exosomes were purified and found to be able to activate vascular endothelial growth factor (VEGF) expression in endothelial cells (ECs). Moreover, exosomes from MSCs and MSCs treated by BYHWD induced elevated microRNA (miRNA)-126 expression and reduced miR-221 and miR-222 expression. In MSCs, disruption of dicer, an enzyme responsible for miRNA maturation, by dicer small interfering RNA (siRNA), or RNase pretreatment abolished this ability of the exosomes. Additionally, exosomes from MSCs treated by BYHWD promoted VEGF and Ki-67 expression and augmented vascular density in rat brain after bilateral carotid artery ligation. In conclusion, our study revealed that BYHWD exposure augmented angiogenetic miRNA and VEGF expression in exosomes secreted by MSCs and elevated angiogenesis in rat brain.

Indexed as

Neovascularization, PhysiologicAnimalsBrain IschemiaCells, CulturedDrugs, Chinese HerbalExosomesMaleMesenchymal Stem CellsMesenchymal Stem Cell TransplantationMicroRNAsRatsRats, Sprague-DawleyUp-RegulationVascular Endothelial Growth Factor Abuyang huanwuDrugs, Chinese HerbalMicroRNAsMIRN221 microRNA, ratMIRN222 microRNA, ratVascular Endothelial Growth Factor A

Identifiers

PMID25796380
OpenAlexW1984829011

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.