Evidence map›Paper›PMID 25796373›Full record

ArticleChild psychiatry and human development2016

Prenatal Maternal Smoking and Tourette Syndrome: A Nationwide Register Study.

Susanna Leivonen, Roshan Chudal, Petteri Joelsson, Mikael Ekblad, Auli Suominen, Alan S Brown, Mika Gissler, Arja Voutilainen, Andre Sourander

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Article in Child psychiatry and human development, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Susanna LeivonenDepartment of Child Psychiatry, University of Turku, Turku, Finland. susanna.leivonen@utu.fi.
Roshan ChudalDepartment of Child Psychiatry, University of Turku, Turku, Finland.
Petteri JoelssonDepartment of Child Psychiatry, University of Turku, Turku, Finland.
Mikael EkbladDepartment of Pediatrics, Turku University Hospital and University of Turku, Turku, Finland.
Auli SuominenDepartment of Child Psychiatry, University of Turku, Turku, Finland.
Alan S BrownDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, NY, USA.
Mika GisslerDepartment of Child Psychiatry, University of Turku, Turku, Finland.
Arja VoutilainenChild Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Andre SouranderDepartment of Child Psychiatry, University of Turku, Turku, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This is the first nationwide register-based study to examine the relationship between prenatal maternal smoking and Tourette syndrome. A total of 767 children diagnosed with Tourette syndrome were identified from the Finnish Hospital Discharge Register. Each case was matched to four controls. Information on maternal smoking during pregnancy was obtained from the Finnish Medical Birth Register. Conditional logistic regression models were used for statistical analyses. Prenatal maternal smoking was associated with Tourette syndrome when comorbid with ADHD (OR 4.0, 95 % CI 1.2-13.5, p = 0.027 for exposure during first trimester, OR 1.7, 95 % CI, 1.05-2.7, p = 0.031 for exposure for the whole pregnancy). There was no association between maternal smoking during pregnancy and Tourette syndrome without comorbid ADHD (OR 0.5, 95 % CI 0.2-1.3, p = 0.166, OR 0.9, 95 % CI 0.7-1.3, p = 0.567). Further research is needed to elucidate the mechanisms behind the association between prenatal maternal smoking and Tourette syndrome with comorbid ADHD.

Indexed as

Attention Deficit Disorder with HyperactivityChildComorbidityFemaleFinlandGestational AgeHumansPregnancyPregnancy Trimester, FirstPrenatal Exposure Delayed EffectsRegistriesSmokingStatistics as TopicTourette SyndromeADHDEpidemiologyPrenatal maternal smokingRegister studyRisk factorTourette syndrome

Identifiers

PMID25796373

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.