ArticleMetabolic brain disease2015
Increased brain iron deposition is a risk factor for brain atrophy in patients with haemodialysis: a combined study of quantitative susceptibility mapping and whole brain volume analysis.
Article in Metabolic brain disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Exploring the role of quantitative susceptibility mapping in assessing brain iron deposition in hemodialysis patients.Insights into imaging · 2026Article
- Different patterns of brain iron deposition exist in peritoneal dialysis and hemodialysis patients with cognitive impairment.Renal failure · 2025Article
- Mild cognitive impairment is associated with effect of uremic metabolites on gray matter structural changes in end-stage kidney disease.Brain imaging and behavior · 2025Article
- Brain Iron Deposition Alterations in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment Based on Quantitative Susceptibility Mapping.Journal of diabetes · 2025Observational
- Combination of rs-fMRI, QSM, and ASL Reveals the Cerebral Neurovascular Coupling Dysfunction Is Associated With Cognitive Decline in Patients With Chronic Kidney Disease.CNS neuroscience & therapeutics · 2024Article
- Combining Quantitative Susceptibility Mapping With the Gray Matter Volume to Predict Neurological Deficits in Patients With Small Artery Occlusion.Brain and behavior · 2024Article
- The covariant structural and functional neuro-correlates of cognitive impairments in patients with end-stage renal diseases.Frontiers in neuroscience · 2024Article
- Abnormal grey matter structural changes in patients with end-stage kidney disease and mild cognitive impairment: correlations with clinical features.Metabolic brain disease · 2023Article
- Dialysis adequacy and hemoglobin levels predict cerebral atrophy in maintenance-hemodialysis patients.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Phase-based masking for quantitative susceptibility mapping of the human brain at 9.4T.Magnetic resonance in medicine · 2022Article
- Reduced cortical complexity in patients with end-stage kidney disease prior to dialysis initiation.Frontiers in neuroscience · 2022Article
- Integrated Prediction Framework for Clinical Scores of Cognitive Functions in ESRD Patients.Computational intelligence and neuroscience · 2022Article
- CAU-Net: A Deep Learning Method for Deep Gray Matter Nuclei Segmentation.Frontiers in neuroscience · 2022Article
- Intradialytic hypotension and relationship with cognitive function and brain morphometry.Clinical kidney journal · 2021Article
- Iron-regulatory genes are associated with Neuroimaging measures in HIV infection.Brain imaging and behavior · 2020Article
- Decreased cerebral blood flow and improved cognitive function in patients with end-stage renal disease after peritoneal dialysis: An arterial spin-labelling study.European radiology · 2019Article
- Resting-state functional MR imaging shed insights into the brain of diabetes.Metabolic brain disease · 2016Review
- Cerebral blood flow changes in hemodialysis and peritoneal dialysis patients: an arterial-spin labeling MR imaging.Metabolic brain disease · 2016Article
- The impact of hemodialysis on cognitive dysfunction in patients with end-stage renal disease: a resting-state functional MRI study.Metabolic brain disease · 2015Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To explore the correlation between increased brain iron deposition and brain atrophy in patients with haemodialysis and their correlation with clinical biomarkers and neuropsychological test. Forty two patients with haemodialysis and forty one age- and gender-matched healthy controls were recruited in this prospective study. 3D whole brain high resolution T1WI and susceptibility weighted imaging were scanned on a 3 T MRI system. The brain volume was analyzed using voxel-based morphometry (VBM) in patients and to compare with that of healthy controls. Quantitative susceptibility mapping was used to measure and compare the susceptibility of different structures between patients and healthy controls. Correlation analysis was used to investigate the relationship between the brain volume, iron deposition and neuropsychological scores. Stepwise multiple regression analysis was used to explore the effect of clinical biomarkers on the brain volumes in patients. Compared with healthy controls, patients with haemodialysis showed decreased volume of bilateral putamen and left insular lobe (All P < 0.05). Susceptibilities of bilateral caudate head, putamen, substantia nigra, red nucleus and dentate nucleus were significantly higher (All P < 0.05). The increased brain iron deposition is negatively correlated with the decreased volume of bilateral putamen (P < 0.01). Neuropsychological scores positively correlated with decreased volume of left insular lobe (P < 0.05). Dialysis duration was negatively associated with decreased volume of bilateral putamen (P < 0.05). Our study indicated increased brain iron deposition and dialysis duration was risk factors for brain atrophy in patients with haemodialysis. The decreased gray matter volume of the left insular lobe was correlated with neurocognitive impairment.
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