ArticleJournal of minimally invasive gynecology
Laparoscopic Fluorescent Visualization of the Ureter With Intravenous IRDye800CW.
Article in Journal of minimally invasive gynecology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Utility of Intraoperative Fluorescence Imaging in Gynecologic Surgery: Systematic Review and Consensus Statement.Annals of surgical oncology · 2021Pooled it
- The sentinel stent? A systematic review of the role of prophylactic ureteric stenting prior to colorectal resections.International journal of colorectal disease · 2019Pooled it
- Currently available and experimental dyes for intraoperative near-infrared fluorescence imaging of the ureters: a systematic review.Techniques in coloproctology · 2019Pooled it
- Computer vision augmented indocyanine green near-infrared fluorescence (ICG-NIRF) signal-to-background ratio (SBR) for identification of extrahepatic biliary structures in laparoscopic cholecystectomy.Surgical endoscopy · 2026Article
- Actionable Feedback on Signal-to-Background Ratios During Drop-in Radioguided Surgery.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- Evaluation of analytical models to estimate depth of fluorescence objects in biological media.Journal of biomedical optics · 2026Article
- Evaluation of the Utilization of Near-Infrared Fluorescent Contrast Agent ASP5354 for In Vivo Ureteral Identification in Renal Diseases Using Rat Models of Gentamicin-Induced Acute Kidney Injury.Diagnostics (Basel, Switzerland) · 2023Article
- Detection of Tumour-Targeted IRDye800CW Tracer with Commercially Available Laparoscopic Surgical Systems.Diagnostics (Basel, Switzerland) · 2023Article
- Quantifying the Impact of Signal-to-background Ratios on Surgical Discrimination of Fluorescent Lesions.Molecular imaging and biology · 2023Article
- Preclinical Development and Validation of ASP5354: A Near-Infrared Fluorescent Agent for Intraoperative Ureter Visualization.Molecular imaging and biology · 2023Article
- In Vivo Optical Imaging of Bladder Cancer Tissues in an MB49 Bladder Cancer Orthotopic Mouse Model Using the Intravesical or Intravenous Administration of Near-Infrared Fluorescence Probe.International journal of molecular sciences · 2023Article
- Urologic Complication after Laparoscopic Hysterectomy in Gynecology Oncology: A Single-Center Analysis and Narrative Review of the Literature.Medicina (Kaunas, Lithuania) · 2022Review
- Computer-Assisted Differentiation between Colon-Mesocolon and Retroperitoneum Using Hyperspectral Imaging (HSI) Technology.Diagnostics (Basel, Switzerland) · 2022Article
- Role of near-infrared fluorescence in colorectal surgery.World journal of gastroenterology · 2021Review
- Ureter Identification In an Inflammatory Pig Model Using a Novel Near-Infrared Fluorescent Dye.Lasers in surgery and medicine · 2020Article
- Prognostic imaging of iatrogenic and traumatic ureteral injury by near-infrared fluorescence.Quantitative imaging in medicine and surgery · 2019Article
- Intraoperative ureter visualization using a near-infrared imaging agent.Journal of biomedical optics · 2019Article
- Emerging Fluorescent Molecular Tracers to Guide Intra-Operative Surgical Decision-Making.Frontiers in pharmacology · 2019Review
- A chemically stable fluorescent marker of the ureter.Bioorganic & medicinal chemistry letters · 2018Article
- Evaluation of a novel dye for near-infrared fluorescence delineation of the ureters during laparoscopy.BJS open · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesUreter injury is a serious complication of laparoscopic surgery. Current strategies to identify the ureters, such as placement of a ureteral stent, carry additional risks for patients. We hypothesize that the systemically injected near-infrared (NIR) dye IRDye800CW-CA can be used to visualize ureters intraoperatively.
methodsAdult female mixed-breed pigs weighing 24 to 41 kg (n = 2 per dose) were given a 30, 60, or 120 μg/kg systemic injection of IRDye800CW-CA. Using the Food and Drug Administration-cleared Pinpoint laparoscopic NIR system, images of the ureter and bladder were captured every 10 minutes for 60 minutes after injection. To determine the biodistribution of the dye, tissues were collected for ex vivo analysis with the Pearl Impulse system. ImageJ software was used to quantify fluorescence signal and signal-to-background ratio (SBR) for the intraoperative images.
resultsThe ureter was identified in all pigs at each dose, with peak intensity reached by 30 minutes and remaining elevated throughout the duration of imaging (60 minutes). The 60 μg/kg dose was determined to be optimal for differentiating ureters according to absolute fluorescence (>60 counts/pixel) and SBR (3.1). Urine fluorescence was inversely related to plasma fluorescence (R(2) = -0.82). Ex vivo imaging of kidney, ureter, bladder, and abdominal wall tissues revealed low fluorescence.
conclusionSystemic administration of IRDye800CW-CA shows promise in providing ureteral identification with high specificity during laparoscopic surgery. The low dose required, rapid time to visualization, and absence of invasive ureteral instrumentation inherent to this technique may reduce complications related to pelvic surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.