Evidence map›Paper›PMID 25796077›Full record

ArticleVirology2015

Decapping protein 1 phosphorylation modulates IL-8 expression during respiratory syncytial virus infection.

Laura L Dickey, Julie K Duncan, Timothy M Hanley, Rachel Fearns

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Strategies for Success. Viral Infections and Membraneless Organelles.Frontiers in cellular and infection microbiology · 2019
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Laura L DickeyDepartment of Microbiology, Boston University, School of Medicine, 72 E. Concord Street, Boston, MA 02118, USA. Electronic address: laura.dickey@path.utah.edu.
Julie K DuncanDepartment of Microbiology, Boston University, School of Medicine, 72 E. Concord Street, Boston, MA 02118, USA. Electronic address: jkdrz3@health.missouri.edu.
Timothy M HanleyDepartment of Microbiology, Boston University, School of Medicine, 72 E. Concord Street, Boston, MA 02118, USA. Electronic address: timothy.hanley@hsc.utah.edu.
Rachel FearnsDepartment of Microbiology, Boston University, School of Medicine, 72 E. Concord Street, Boston, MA 02118, USA. Electronic address: rfearns@bu.edu.
Boston University · US

Funding

Respiratory Syncytial Virus Polymerase Protein and Promoter InteractionsR01AI074903 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FEARNS, RACHEL · 2008 to 2011
$1.6M
NIAID NIH HHS R01 AI074903NIAID NIH HHS R01AI074903
6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) is a negative-strand RNA virus that is an important cause of bronchiolitis and pneumonia. We investigated the effect of RSV infection on the expression patterns of cellular proteins involved in regulating mRNA translation and degradation, and found that a processing-body protein involved in mRNA degradation, decapping protein 1a (DCP1), was phosphorylated rapidly following infection. UV-inactivated and sucrose-purified RSV were sufficient to mediate DCP1 phosphorylation, indicating that it occurs as a consequence of an early event in RSV infection. Analysis using kinase inhibitors showed that RSV-induced DCP1 phosphorylation occurred through the ERK1/2 pathway. The DCP1 phosphorylation sites were limited to serine 315, serine 319, and threonine 321. Overexpression of wt DCP1 led to a decrease in RSV-induced IL-8 production, but this effect was abrogated in cells overexpressing phosphorylation-deficient DCP1 mutants. These results suggest that DCP1 phosphorylation modulates the host chemokine response to RSV infection.

Indexed as

Amino Acid MotifsEndoribonucleasesExtracellular Signal-Regulated MAP KinasesHep G2 CellsHumansInterleukin-8PhosphorylationRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsTrans-ActivatorsDCP1A protein, humanEndoribonucleasesExtracellular Signal-Regulated MAP KinasesInterleukin-8Trans-ActivatorsDCP1aDecapping protein 1aIL-8Processing bodiesRespiratory syncytial virusStress granules

Identifiers

PMID25796077
PMCPMC4437874
OpenAlexW2047458227

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.