ArticleSocial science & medicine (1982)2015
Bioidentical hormones, menopausal women, and the lure of the "natural" in U.S. anti-aging medicine.
Article in Social science & medicine (1982), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Estradiol and progesterone bioavailability for moderate to severe vasomotor symptom treatment and endometrial protection with the continuous-combined regimen of TX-001HR (oral estradiol and progesterone capsules).Menopause (New York, N.Y.) · 2019Trial
- Oral 17β-estradiol/progesterone (TX-001HR) and quality of life in postmenopausal women with vasomotor symptoms.Menopause (New York, N.Y.) · 2019Trial
- Evaluation of clinical meaningfulness of estrogen plus progesterone oral capsule (TX-001HR) on moderate to severe vasomotor symptoms.Menopause (New York, N.Y.) · 2019Trial
- The REJOICE trial: a phase 3 randomized, controlled trial evaluating the safety and efficacy of a novel vaginal estradiol soft-gel capsule for symptomatic vulvar and vaginal atrophy.Menopause (New York, N.Y.) · 2017Trial
- Assessing the Roles of Aging, Estrogen, Nutrition, and Neuroinflammation in Women and Their Involvement in Alzheimer's Disease-A Narrative Overview.International journal of molecular sciences · 2026Review
- Living with acuteness in chronic illness: The temporal underpinnings of endometriosis.Medical anthropology quarterly · 2025Article
- Beyond Estrogen: Unraveling the Complexities of Hormonal Signaling Pathways in Alzheimer's Disease and Their Implications for Precision Therapy.Molecular neurobiology · 2025Review
- The role of estrogen in Alzheimer's disease pathogenesis and therapeutic potential in women.Molecular and cellular biochemistry · 2025Review
- Legitimacy as Social Infrastructure: A Critical Interpretive Synthesis of the Literature on Legitimacy in Health and Technology.JMIR human factors · 2025Review
- Fear, misinformation, and pharmaceutical messianism in the promotion of compounded bioidentical hormone therapy.Frontiers in reproductive health · 2024Article
- Changes in the mammary gland during aging and its links with breast diseases.Acta biochimica et biophysica Sinica · 2023Review
- Physiological Concentrations ofBiomolecules · 2022Article
- Increased Incidence of Endometrial Cancer Following the Women's Health Initiative: An Assessment of Risk Factors.Journal of women's health (2002) · 2019Article
- Interaction between cardiovascular autonomic control and sex hormones in perimenopausal women under menopausal hormone therapy.Cardiovascular endocrinology & metabolism · 2018Article
- Why women choose compounded bioidentical hormone therapy: lessons from a qualitative study of menopausal decision-making.BMC women's health · 2017Article
- Prescribing of FDA-approved and compounded hormone therapy differs by specialty.Menopause (New York, N.Y.) · 2016Article
- Update on primary ovarian insufficiency.Current opinion in endocrinology, diabetes, and obesity · 2015Review
- Compounded bioidentical hormone products, a path forward.Journal of the American Pharmacists Association : JAPhAArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In 2002, the Women's Health Initiative, a large-scale study of the safety of hormone replacement therapy (HRT) for women conducted in the United States, released results suggesting that use of postmenopausal HRT increased women's risks of stroke and breast cancer. In the years that followed, as rates of HRT prescription fell, another hormonal therapy rose in its wake: bioidentical hormone replacement therapy (BHRT). Anti-aging clinicians, the primary prescribers of BHRT, tout it as a safe and effective alternative to treat menopausal symptoms and, moreover, as a preventative therapy for age-related diseases and ailments. Through in-depth interviews with 31 U.S.-based anti-aging clinicians and 25 female anti-aging patients, we analyze attitudes towards BHRT. We illustrate how these attitudes reveal broader contemporary values, discourses, and discomforts with menopause, aging, and biomedicine. The attraction to and promise of BHRT is rooted in the idea that it is a "natural" therapy. BHRT is given both biomedical and embodied legitimacy by clinicians and patients because of its purported ability to become part of the body's "natural" processes. The normative assumption that "natural" is inherently "good" not only places BHRT beyond reproach, but transforms its use into a health benefit. The clinical approach of anti-aging providers also plays a role by validating patients' embodied experiences and offering a "holistic" solution to their symptoms, which anti-aging patients see as a striking contrast to their experiences with conventional biomedical health care. The perceived virtues of BHRT shed light on the rhetoric of anti-aging medicine and a deeply complicated relationship between conventional biomedicine, hormonal technologies, and women's bodies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.