Evidence map›Paper›PMID 25795991›Full record

ArticleSocial science & medicine (1982)2015

Bioidentical hormones, menopausal women, and the lure of the "natural" in U.S. anti-aging medicine.

Jennifer R Fishman, Michael A Flatt, Richard A Settersten

Abstract read
In one paragraph

Article in Social science & medicine (1982), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  17. Update on primary ovarian insufficiency.Current opinion in endocrinology, diabetes, and obesity · 2015
    Review
  18. Compounded bioidentical hormone products, a path forward.Journal of the American Pharmacists Association : JAPhA
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jennifer R FishmanSocial Studies of Medicine Department, Biomedical Ethics Unit. McGill University, 3647 Peel Street, Montreal, Quebec H3A 1X1, Canada. Electronic address: jennifer.fishman@mcgill.ca.
Michael A FlattDepartment of Bioethics, Case Western Reserve University, 10900 Euclid Avenue, TA-200, Cleveland, OH 44106-4976, USA. Electronic address: michael.flatt@case.edu.
Richard A SetterstenSocial and Behavioral Health Sciences, College of Public Health and Human Sciences, Oregon State University, 2631 SW Campus Way, Corvallis, OR 97331, USA. Electronic address: richard.settersten@oregonstate.edu.

Funding

Enhancement Ethics and the Molecular Genetics of AgingR01AG020916 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI JUENGST, ERIC T · 2001 to 2010
$2.3M
NIA NIH HHS R01 AG020916NIA NIH HHS R01AG020916
6 · The paper itself

Abstract

In 2002, the Women's Health Initiative, a large-scale study of the safety of hormone replacement therapy (HRT) for women conducted in the United States, released results suggesting that use of postmenopausal HRT increased women's risks of stroke and breast cancer. In the years that followed, as rates of HRT prescription fell, another hormonal therapy rose in its wake: bioidentical hormone replacement therapy (BHRT). Anti-aging clinicians, the primary prescribers of BHRT, tout it as a safe and effective alternative to treat menopausal symptoms and, moreover, as a preventative therapy for age-related diseases and ailments. Through in-depth interviews with 31 U.S.-based anti-aging clinicians and 25 female anti-aging patients, we analyze attitudes towards BHRT. We illustrate how these attitudes reveal broader contemporary values, discourses, and discomforts with menopause, aging, and biomedicine. The attraction to and promise of BHRT is rooted in the idea that it is a "natural" therapy. BHRT is given both biomedical and embodied legitimacy by clinicians and patients because of its purported ability to become part of the body's "natural" processes. The normative assumption that "natural" is inherently "good" not only places BHRT beyond reproach, but transforms its use into a health benefit. The clinical approach of anti-aging providers also plays a role by validating patients' embodied experiences and offering a "holistic" solution to their symptoms, which anti-aging patients see as a striking contrast to their experiences with conventional biomedical health care. The perceived virtues of BHRT shed light on the rhetoric of anti-aging medicine and a deeply complicated relationship between conventional biomedicine, hormonal technologies, and women's bodies.

Indexed as

AgingAttitude to HealthBiological ProductsEstrogen Replacement TherapyFemaleHumansInterviews as TopicMenopauseUnited StatesWomen's HealthBiological ProductsAgingAnti-agingBioidentical hormonesBiomedicineHormone replacement therapyMenopauseUnited StatesWomen's health

Identifiers

PMID25795991
PMCPMC4400226

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.