Evidence map›Paper›PMID 25795789›Full record

ReviewJournal of immunology (Baltimore, Md. : 1950)2015

Tumor-infiltrating dendritic cells in cancer pathogenesis.

Jo Marie Tran Janco, Purushottam Lamichhane, Lavakumar Karyampudi, Keith L Knutson

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of immunology (Baltimore, Md. : 1950), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 256 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
256citing papers in PubMed, 1 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

256 citing papers in PubMed, 1 synthesis or guideline pooled it, 420 citations in OpenAlex.

  1. Pooled it
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  9. Peptide vaccine formulations with structurally distinct STING agonist drugamers induce discrete, efficacious antitumor responses.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Myeloid cells in chronic liver inflammation.Cellular & molecular immunology · 2025
    Review
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196 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Jo Marie Tran JancoDivision of Gynecologic Surgery, Mayo Clinic, Rochester, MN 55906;
Purushottam LamichhaneDepartment of Immunology, Mayo Clinic, Rochester, MN 55906; and Cancer Vaccines and Immune Therapies Program, Vaccine and Gene Therapy Institute, Port St. Lucie, FL 34987.
Lavakumar KaryampudiCancer Vaccines and Immune Therapies Program, Vaccine and Gene Therapy Institute, Port St. Lucie, FL 34987.
Keith L KnutsonDepartment of Immunology, Mayo Clinic, Rochester, MN 55906; and Cancer Vaccines and Immune Therapies Program, Vaccine and Gene Therapy Institute, Port St. Lucie, FL 34987 knutson.keith@mayo.edu.
Mayo Clinic in Arizona · USMayo Clinic in Florida · USVaccine and Gene Therapy InstituteVaccine & Gene Therapy Institute of Florida · US

Funding

Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI Zhenkun Lou · 2009 to 2026
$37.0M
NCI NIH HHS P50 CA136393NCI NIH HHS P50-CA136393
6 · The paper itself

Abstract

Dendritic cells (DCs) play a pivotal role in the tumor microenvironment, which is known to affect disease progression in many human malignancies. Infiltration by mature, active DCs into the tumors confers an increase in immune activation and recruitment of disease-fighting immune effector cells and pathways. DCs are the preferential target of infiltrating T cells. However, tumor cells have means of suppressing DC function or of altering the tumor microenvironment in such a way that immune-suppressive DCs are recruited. Advances in understanding these changes have led to promising developments in cancer-therapeutic strategies targeting tumor-infiltrating DCs to subdue their immunosuppressive functions and enhance their immune-stimulatory capacity.

Indexed as

Adaptive ImmunityAnimalsDendritic CellsHumansImmune ToleranceImmunotherapyNeoplasmsPhenotypeTranscription FactorsTranscription Factors

Identifiers

PMID25795789
PMCPMC4369768
OpenAlexW1823780969

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.