ArticleBrain : a journal of neurology2015
Autism: reduced connectivity between cortical areas involved in face expression, theory of mind, and the sense of self.
Article in Brain : a journal of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
121 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Resting-state abnormalities in Autism Spectrum Disorders: A meta-analysis.Scientific reports · 2019Pooled it
- Brain-Wide Analysis of Functional Connectivity in First-Episode and Chronic Stages of Schizophrenia.Schizophrenia bulletin · 2017Pooled it
- Brain Functional Network in Chronic Asymptomatic Carotid Artery Stenosis and Occlusion: Changes and Compensation.Neural plasticity · 2020Trial
- Depression: higher temporal variability of the functional connectivity of the ventromedial prefrontal cortex and hippocampal system.NeuroImage. Clinical · 2026Article
- Aberrant multivariate mapping between behavioral profiles and cortical morphological brain networks in children with autism spectrum disorder.Translational psychiatry · 2026Article
- Changes in Intrinsic Activity of the Primary Somatosensory Cortex Causally Explain Differences in Emotion Perception in Autism.Autism research : official journal of the International Society for Autism Research · 2026Article
- Visual Cortical Lateralization in Activations and Functional Connectivity to the Sight of Faces, Scenes, Body Parts, and Tools.Human brain mapping · 2026Article
- Core-Periphery Principle Guided State Space Model for Functional Connectome Classification.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2026Article
- Autistic traits and proneness to shame and guilt: The mediating role of functional connectivity of cortical midline structures.Personality neuroscience · 2026Article
- Repetitive transcranial magnetic stimulation-driven modulation of unbiased functional connectivity in the supracallosal anterior cingulate cortex causally ameliorates information processing speed in amnestic mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Identification of critical brain regions for autism diagnosis from fMRI data using explainable AI: an observational analysis of the ABIDE dataset.EClinicalMedicine · 2025Article
- Contrast subgraphs catch patterns of altered functional connectivity in autism spectrum disorder.Scientific reports · 2025Article
- A functional parcellation of the whole brain in high-functioning individuals with autism spectrum disorder reveals atypical patterns of network organization.Molecular psychiatry · 2025Article
- Dynamic functional adaptations during touch observation in autism: connectivity strength is linked to attitudes towards social touch and social responsiveness.Molecular autism · 2025Article
- Adaptive Whole-Brain Dynamics Predictive Method: Relevancy to Mental Disorders.Research (Washington, D.C.) · 2025Article
- VAE deep learning model with domain adaptation, transfer learning and harmonization for diagnostic classification from multi-site neuroimaging data.Frontiers in neuroinformatics · 2025Article
- Hippocampal Discoveries: Spatial View Cells, Connectivity, and Computations for Memory and Navigation, in Primates Including Humans.Hippocampus · 2025Review
- Disrupted Brain Network Measures in Parkinson's Disease Patients with Severe Hyposmia and Cognitively Normal Ability.Brain sciences · 2024Article
- The Relationship Between Brain Activation for Taking Others' Perspective and Interoceptive Abilities in Autism Spectrum Disorder: An fMRI Study.Journal of the Korean Academy of Child and Adolescent Psychiatry · 2024Article
- Selective activations and functional connectivities to the sight of faces, scenes, body parts and tools in visual and non-visual cortical regions leading to the human hippocampus.Brain structure & function · 2024Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whole-brain voxel-based unbiased resting state functional connectivity was analysed in 418 subjects with autism and 509 matched typically developing individuals. We identified a key system in the middle temporal gyrus/superior temporal sulcus region that has reduced cortical functional connectivity (and increased with the medial thalamus), which is implicated in face expression processing involved in social behaviour. This system has reduced functional connectivity with the ventromedial prefrontal cortex, which is implicated in emotion and social communication. The middle temporal gyrus system is also implicated in theory of mind processing. We also identified in autism a second key system in the precuneus/superior parietal lobule region with reduced functional connectivity, which is implicated in spatial functions including of oneself, and of the spatial environment. It is proposed that these two types of functionality, face expression-related, and of one's self and the environment, are important components of the computations involved in theory of mind, whether of oneself or of others, and that reduced connectivity within and between these regions may make a major contribution to the symptoms of autism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.