Evidence map›Paper›PMID 25795455›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2015

Masticatory muscles of mouse do not undergo atrophy in space.

Anastassios Philippou, Fabio C Minozzo, Janelle M Spinazzola, Lucas R Smith, Hanqin Lei, Dilson E Rassier, Elisabeth R Barton

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Aging and Altered Gravity: A Cellular Perspective.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. The Effects of Muscle Cell Aging on Myogenesis.International journal of molecular sciences · 2021
    Article
  9. The Impact of Spaceflight and Simulated Microgravity on Cell Adhesion.International journal of molecular sciences · 2020
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Anastassios Philippou*Department of Physiology, Medical School, National and Kapodistrian University of Athens, Goudi-Athens, Greece; Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Kinesiology, McGill University, Montreal, Quebec, Canada; Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA; and Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Fabio C Minozzo*Department of Physiology, Medical School, National and Kapodistrian University of Athens, Goudi-Athens, Greece; Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Kinesiology, McGill University, Montreal, Quebec, Canada; Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA; and Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Janelle M Spinazzola*Department of Physiology, Medical School, National and Kapodistrian University of Athens, Goudi-Athens, Greece; Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Kinesiology, McGill University, Montreal, Quebec, Canada; Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA; and Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Lucas R Smith*Department of Physiology, Medical School, National and Kapodistrian University of Athens, Goudi-Athens, Greece; Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Kinesiology, McGill University, Montreal, Quebec, Canada; Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA; and Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Hanqin Lei*Department of Physiology, Medical School, National and Kapodistrian University of Athens, Goudi-Athens, Greece; Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Kinesiology, McGill University, Montreal, Quebec, Canada; Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA; and Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Dilson E Rassier*Department of Physiology, Medical School, National and Kapodistrian University of Athens, Goudi-Athens, Greece; Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Kinesiology, McGill University, Montreal, Quebec, Canada; Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA; and Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Elisabeth R Barton*Department of Physiology, Medical School, National and Kapodistrian University of Athens, Goudi-Athens, Greece; Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Kinesiology, McGill University, Montreal, Quebec, Canada; Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA; and Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA erbarton@ufl.edu.
University of Pennsylvania · USMcGill University · CANational and Kapodistrian University of Athens · GRUniversity of Florida · US

Funding

Training and education CoreU54AR052646 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MCNALLY, ELIZABETH M, SWEENEY, H LEE · 2005 to 2020
$24.1M
Canadian Institutes of Health ResearchNIAMS NIH HHS U54 AR052646PHS HHS R052646
6 · The paper itself

Abstract

Muscle loading is important for maintaining muscle mass; when load is removed, atrophy is inevitable. However, in clinical situations such as critical care myopathy, masticatory muscles do not lose mass. Thus, their properties may be harnessed to preserve mass. We compared masticatory and appendicular muscles responses to microgravity, using mice aboard the space shuttle Space Transportation System-135. Age- and sex-matched controls remained on the ground. After 13 days of space flight, 1 masseter (MA) and tibialis anterior (TA) were frozen rapidly for biochemical and functional measurements, and the contralateral MA was processed for morphologic measurements. Flight TA muscles exhibited 20 ± 3% decreased muscle mass, 2-fold decreased phosphorylated (P)-Akt, and 4- to 12-fold increased atrogene expression. In contrast, MAs had no significant change in mass but a 3-fold increase in P-focal adhesion kinase, 1.5-fold increase in P-Akt, and 50-90% lower atrogene expression compared with limb muscles, which were unaltered in microgravity. Myofibril force measurements revealed that microgravity caused a 3-fold decrease in specific force and maximal shortening velocity in TA muscles. It is surprising that myofibril-specific force from both control and flight MAs were similar to flight TA muscles, yet power was compromised by 40% following flight. Continued loading in microgravity prevents atrophy, but masticatory muscles have a different set point that mimics disuse atrophy in the appendicular muscle.

Indexed as

Space FlightAnimalsBiomechanical PhenomenaFemaleGene ExpressionMasticationMasticatory MusclesMiceMice, Inbred C57BLMuscle ContractionMuscle ProteinsMuscle, SkeletalMuscular AtrophyMyofibrilsSKP Cullin F-Box Protein LigasesTripartite Motif ProteinsFbxo32 protein, mouseMuscle ProteinsSKP Cullin F-Box Protein LigasesTrim63 protein, mouseTripartite Motif ProteinsUbiquitin-Protein Ligasesatrogenesmicrogravitymuscle adaptations

Identifiers

PMID25795455
PMCPMC4478801
OpenAlexW1976916493

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.