Evidence map›Paper›PMID 25795343›Full record

ArticleNeuroImage2015

Risky decision-making and ventral striatal dopamine responses to amphetamine: a positron emission tomography [(11)C]raclopride study in healthy adults.

Lynn M Oswald, Gary S Wand, Dean F Wong, Clayton H Brown, Hiroto Kuwabara, James R Brašić

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Amplified Striatal Responses to Near-Miss Outcomes in Pathological Gamblers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016
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  15. Evaluating the evidence for sex differences: a scoping review of human neuroimaging in psychopharmacology research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lynn M OswaldDepartment of Family and Community Health, University of Maryland School of Nursing, Baltimore, MD 21201, USA; Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: oswald@son.umaryland.edu.
Gary S WandDepartment of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Dean F WongDepartment of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Environmental Health Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Clayton H BrownDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Hiroto KuwabaraThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
James R BrašićThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Johns Hopkins University · USUniversity of Maryland, Baltimore · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Zonulin Antibodies in Intestinal Permeabilitiy in IDDMM01RR016500 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI OSWALD, LYNN M · 2002 to 2009
$20.2M
Mechanisms of Dopamine and Serotonin in Tourette SyndromeR01MH078175 · NIMH · JOHNS HOPKINS UNIVERSITY · PI WONG, DEAN FOSTER · 2006 to 2011
$3.0M
Imaging Research on Impulsivity, Stress and Drug AbuseR01DA022433 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI OSWALD, LYNN M · 2008 to 2012
$2.9M
Neuroendocrine Investigators and Mentoring in the field of Alcohol ResearchK05AA020342 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI WAND, GARY S · 2011 to 2015
$872k
NCATS NIH HHS UL1 TR 001079NCATS NIH HHS UL1 TR001079NCRR NIH HHS M01 RR016500NIAAA NIH HHS K05 AA020342NIDA NIH HHS R01 DA022433NIMH NIH HHS R01 MH078175
6 · The paper itself

Abstract

Recent functional magnetic resonance imaging (fMRI) studies have provided compelling evidence that corticolimbic brain regions are integrally involved in human decision-making. Although much less is known about molecular mechanisms, there is growing evidence that the mesolimbic dopamine (DA) neurotransmitter system may be an important neural substrate. Thus far, direct examination of DA signaling in human risk-taking has centered on gambling disorder. Findings from several positron emission tomography (PET) studies suggest that dysfunctions in mesolimbic DA circuits may play an important role in gambling behavior. Nevertheless, interpretation of these findings is currently hampered by a need for better understanding of how individual differences in regional DA function influence normative decision-making in humans. To further our understanding of these processes, we used [(11)C]raclopride PET to examine associations between ventral striatal (VS) DA responses to amphetamine (AMPH) and risky decision-making in a sample of healthy young adults with no history of psychiatric disorder, Forty-five male and female subjects, ages 18-29 years, completed a computerized version of the Iowa Gambling Task. Participants then underwent two 90-minute PET studies with high specific activity [(11)C]raclopride. The first scan was preceded by intravenous saline; the second, by intravenous AMPH (0.3mg/kg). Findings of primary analyses showed that less advantageous decision-making was associated with greater right VS DA release; the relationship did not differ as a function of gender. No associations were observed between risk-taking and left VS DA release or baseline D2/D3 receptor availability in either hemisphere. Overall, the results support notions that variability in striatal DA function may mediate inter-individual differences in risky decision-making in healthy adults, further suggesting that hypersensitive DA circuits may represent a risk pathway in this population.

Indexed as

Risk-TakingAdolescentAdultAmphetamineCentral Nervous System StimulantsDecision MakingDopamineDopamine Uptake InhibitorsFemaleGamblingHumansIndividualityMagnetic Resonance ImagingMaleNeuropsychological TestsPositron-Emission TomographyAmphetamineCentral Nervous System StimulantsDopamineDopamine Uptake InhibitorsRacloprideReceptors, Dopamine D2Receptors, Dopamine D3AmphetamineDecision-makingDopamineHumanPositron emission tomography (PET)Ventral striatum

Identifiers

PMID25795343
PMCPMC4433778
OpenAlexW2053970789

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.