ArticleThe Libyan journal of medicine2015
Association between vitamin D receptor gene polymorphisms and chronic periodontitis among Libyans.
Article in The Libyan journal of medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 25 citations in OpenAlex.
- Association of Vitamin D Receptor Gene Polymorphisms with Periodontitis.Journal of dentistry (Shiraz, Iran) · 2026Article
- A brief review of vitamin D as a potential target for the regulation of blood glucose and inflammation in diabetes-associated periodontitis.Molecular and cellular biochemistry · 2022Review
- Profile of vitamin D receptor gene polymorphism TaqI in patients with periodontitis.Biomedical reports · 2022Article
- Association between periodontitis and vitamin D status: A case-control study.Saudi journal of biological sciences · 2021Article
- Correlation of vitamin D receptor gene (ApaI) polymorphism with periodontitis: A meta-analysis of Chinese population.Food science & nutrition · 2019Article
- Immunomodulatory factors gene polymorphisms in chronic periodontitis: an overview.BMC oral health · 2019Review
- Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents.Clinical and experimental dental research · 2016Article
- Association of vitamin D receptor BsmI, TaqI, FokI, and ApaI polymorphisms with susceptibility of chronic periodontitis: A systematic review and meta-analysis based on 38 case -control studies.Dental research journalReview
- Estimation of Vitamin D Levels Using a Chairside Diagnostic Test Kit in Patients with Gingivitis and Periodontitis: A Cross-Sectional Study.Journal of International Society of Preventive & Community DentistryArticle
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10 authors at 3 institutions in 1 country.
Funding
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Abstract
backgroundChronic periodontitis (CP) is a common oral disease characterized by inflammation in the supporting tissue of the teeth 'the periodontium', periodontal attachment loss, and alveolar bone loss. The disease has a microbial etiology; however, recent findings suggest that the genetic factors, such as vitamin D receptor (VDR) gene polymorphisms, have also been included.
aimInvestigation of the relationship between VDR gene polymorphisms and CP among Libyans. MATERIALS AND
methodsIn this study, we examined 196 unrelated Libyans between the ages of 25 and 65 years, including 99 patients and 97 controls. An oral examination based on Ramfjord Index was performed at different dental clinics in Tripoli and information were collected using a self-reported questionnaire. DNA was extracted from buccal swabs; the VDR ApaI, BsmI, and FokI polymorphisms were genotyped using polymerase chain reaction and were sequenced using Sanger Method.
resultsA significant difference in the newly detected ApaI SNP C/T rs#731236 was found (p=0.022), whereas no significant differences were found in ApaI SNP G/T rs#7975232, BsmI SNP A/G rs#1544410, and FokI SNP A/G rs#2228570 between patients and controls (p=0.939, 0.466, 0.239), respectively.
conclusionVDR ApaI SNP C/T rs#731236 may be related to the risk of CP in the Libyan population.
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