ReviewCurrent pain and headache reports2015
High-altitude headache.
Review in Current pain and headache reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Interventions for preventing high altitude illness: Part 2. Less commonly-used drugs.The Cochrane database of systematic reviews · 2018Pooled it
- 6-hydroxygenistein attenuates hypoxia-induced injury via activating Nrf2/HO-1 signaling pathway in PC12 cells.Scientific reports · 2025Article
- Parietal-specific activation reveals pain from inadequate levels of altitude acclimatization/ adaptation.PloS one · 2025Article
- Impact of high-altitude exposure on cerebral lobe functions in climbers: insights from the Nepali Himalayas.Frontiers in systems neuroscience · 2025Article
- Dynamics in the prevalence and clinical manifestations of acute mountain sickness of different ascent protocols during high altitudes exposure.Frontiers in public health · 2024Article
- The combined use of acetazolamide andAnnals of translational medicine · 2022Article
- New Insights on Metabolic and Genetic Basis of Migraine: Novel Impact on Management and Therapeutical Approach.International journal of molecular sciences · 2022Review
- Thickened Retinal Nerve Fiber Layers Associated With High-Altitude Headache.Frontiers in physiology · 2022Article
- Sleep, short-term memory, and mood states of volunteers with increasing altitude.Frontiers in psychiatry · 2022Article
- A hypothetical proposal for association between migraine and Meniere's disease.Medical hypotheses · 2020Article
- Association ofBioMed research international · 2020Article
- Chronic Exposure to High Altitude: Synaptic, Astroglial and Memory Changes.Scientific reports · 2019Article
- Triggers, Protectors, and Predictors in Episodic Migraine.Current pain and headache reports · 2018Review
- Hematological Risk Factors for High-Altitude Headache in Chinese Men Following Acute Exposure at 3,700 m.Frontiers in physiology · 2017Article
- Identification of novel serum peptide biomarkers for high-altitude adaptation: a comparative approach.Scientific reports · 2016Article
- Acute mountain sickness among tourists visiting the high-altitude city of Lhasa at 3658 m above sea level: a cross-sectional study.Archives of public health = Archives belges de sante publique · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-altitude headache is one of many neurological symptoms associated with the ascent to high altitudes. Cellular hypoxia due to decreased barometric pressure seems to be the common final pathway for headache as altitude increases. Susceptibility to high-altitude headache depends on genetic factors, history of migraine, and acclimatization, but symptoms of acute mountain sickness are universal at very high altitudes. This review summarizes the pathophysiology of acute mountain sickness and high-altitude headache as well as the evidence for treatment and prevention with different drugs and devices which may be useful for regular and novice mountaineers. This includes an examination of other headache disorders which may mimic high-altitude headache.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.