Evidence map›Paper›PMID 25794950›Full record

ArticleMethods (San Diego, Calif.)2015

Fabrication of tissue engineered osteochondral grafts for restoring the articular surface of diarthrodial joints.

Brendan L Roach, Clark T Hung, James L Cook, Gerard A Ateshian, Andrea R Tan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods (San Diego, Calif.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Articular Cartilage Regeneration in Veterinary Medicine.Advances in experimental medicine and biology · 2022
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Brendan L RoachColumbia University, Department of Biomedical Engineering, New York, NY, USA.
Clark T HungColumbia University, Department of Biomedical Engineering, New York, NY, USA.
James L CookUniversity of Missouri, Comparative Orthopaedic Laboratory, Columbia, MO, USA.
Gerard A AteshianColumbia University, Department of Mechanical Engineering, New York, NY, USA.
Andrea R TanColumbia University, Department of Biomedical Engineering, New York, NY, USA. Electronic address: art2122@columbia.edu.

Funding

Optimizing Nutrient Supply in Large Engineered Cartilage Tissue ConstructsR01AR060361 · NIAMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI ATESHIAN, GERARD A., HUNG, CLARK T. · 2010 to 2014
$1.7M
Multidisciplinary Engineering Training in Musculoskeletal ResearchT32AR059038 · NIAMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI ATESHIAN, GERARD A. · 2011 to 2015
$1.3M
NIAMS NIH HHS R01 AR060361NIAMS NIH HHS R01 AR60361NIAMS NIH HHS T32 AR059038
6 · The paper itself

Abstract

Osteochondral allograft implantation is an effective cartilage restoration technique for large defects (>10 cm(2)), though the demand far exceeds the supply of available quality donor tissue. Large bilayered engineered cartilage tissue constructs with accurate anatomical features (i.e. contours, thickness, architecture) could be beneficial in replacing damaged tissue. When creating these osteochondral constructs, however, it is pertinent to maintain biofidelity to restore functionality. Here, we describe a step-by-step framework for the fabrication of a large osteochondral construct with correct anatomical architecture and topology through a combination of high-resolution imaging, rapid prototyping, impression molding, and injection molding.

Indexed as

AnimalsCartilage, ArticularChondrocytesDogsFemurImaging, Three-DimensionalModels, AnatomicModels, AnimalSurface PropertiesTissue EngineeringAnatomical contourImpression moldingInjection moldingOsteochondral graftRapid prototyping

Identifiers

PMID25794950
PMCPMC4667358

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.