ArticleThe Plant cell2015
Cleavage of INDOLE-3-ACETIC ACID INDUCIBLE28 mRNA by microRNA847 upregulates auxin signaling to modulate cell proliferation and lateral organ growth in Arabidopsis.
Article in The Plant cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 93 citations in OpenAlex.
- Imperative roles of auxin signaling in reprogramming of drought tolerance in plants.Plant cell reports · 2026Review
- miRNA-targeted auxin nuclear signalling elements orchestrate flower fate and drought response in yellow lupine.Scientific reports · 2025Article
- Auxin-salicylic acid seesaw regulates the age-dependent balance between plant growth and herbivore defense.Science advances · 2025Article
- Single-cell RNA sequencing of shoot apex reveals the mechanism of cyclin regulating cell division via auxin signaling pathway inFrontiers in plant science · 2025Article
- TheGenes · 2024Article
- Overexpression of Auxin/Indole-3-Acetic Acid Gene TrIAA27 Enhances Biomass, Drought, and Salt Tolerance inPlants (Basel, Switzerland) · 2024Article
- Analyzing the defense response mechanism ofFrontiers in plant science · 2024Article
- Study on the Interactions of Cyclins with CDKs Involved in Auxin Signal during Leaf Development by WGCNA inInternational journal of molecular sciences · 2023Article
- Genome-wide identification of auxin-responsive microRNAs in the poplar stem.Genes & genomics · 2023Article
- The microRNA ppe-miR393 mediates auxin-induced peach fruit softening by promoting ethylene production.Plant physiology · 2023Article
- Involvement of miRNAs in Metabolic Herbicide Resistance to Bispyribac-Sodium inPlants (Basel, Switzerland) · 2022Article
- SICKLE modulates lateral root development by promoting degradation of lariat intronic RNA.Plant physiology · 2022Article
- The Characters of Non-Coding RNAs and Their Biological Roles in Plant Development and Abiotic Stress Response.International journal of molecular sciences · 2022Review
- Article
- Roles of microRNAs in abiotic stress response and characteristics regulation of plant.Frontiers in plant science · 2022Review
- Differential Responses of Wheat (Frontiers in plant science · 2022Article
- Article
- microRNAs and Their Roles in Plant Development.Frontiers in plant science · 2022Review
- Regulation of pri-MIRNA processing: mechanistic insights into the miRNA homeostasis in plant.Plant cell reports · 2021Review
- Genetic dissection of the auxin response network.Nature plants · 2020Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs function in a range of developmental processes. Here, we demonstrate that miR847 targets the mRNA of the auxin/indole acetic acid (Aux/IAA) repressor-encoding gene IAA28 for cleavage. The rapidly increased accumulation of miR847 in Arabidopsis thaliana coincided with reduced IAA28 mRNA levels upon auxin treatment. This induction of miR847 by auxin was abolished in auxin receptor tir1-1 and auxin-resistant axr1-3 mutants. Further analysis demonstrates that miR847 functions as a positive regulator of auxin-mediated lateral organ development by cleaving IAA28 mRNA. Importantly, the ectopic expression of miR847 increases the expression of cell cycle genes as well as the neoplastic activity of leaf cells, prolonging later-stage rosette leaf growth and producing leaves with serrated margins. Moreover, both miR847 and IAA28 mRNAs are specifically expressed in marginal meristems of rosette leaves and lateral root initiation sites. Our data indicate that auxin-dependent induction of miR847 positively regulates meristematic competence by clearing IAA28 mRNA to upregulate auxin signaling, thereby determining the duration of cell proliferation and lateral organ growth in Arabidopsis. IAA28 mRNA encodes an Aux/IAA repressor protein, which is degraded through the proteasome in response to auxin. Altered signal sensitization to IAA28 mRNA levels, together with targeted IAA28 degradation, ensures a robust signal derepression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.