ArticleAnnals of epidemiology2015
A population-based prospective birth cohort study of childhood neurocognitive and psychological functioning in healthy survivors of early life meningitis.
Article in Annals of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Article
- Subjective experience of meningitis survivors: a transversal qualitative study using interpretative phenomenological analysis.BMJ open · 2020Article
- Systemic inflammation and intelligence in early adulthood and subsequent risk of schizophrenia and other non-affective psychoses: a longitudinal cohort and co-relative study.Psychological medicine · 2019Article
- Association of Childhood Infection With IQ and Adult Nonaffective Psychosis in Swedish Men: A Population-Based Longitudinal Cohort and Co-relative Study.JAMA psychiatry · 2018Article
- Association between childhood infection, serum inflammatory markers and intelligence: findings from a population-based prospective birth cohort study.Epidemiology and infection · 2018Article
- The impact of health on economic and social outcomes in the United Kingdom: A scoping literature review.PloS one · 2018Article
- Neuropsychological and internalizing problems in acute central nervous system infections: a 1 year follow-up.Italian journal of pediatrics · 2017Article
- Short-term changes in the health state of children with group B meningococcal disease: A prospective, national cohort study.PloS one · 2017Article
- Serum C-reactive protein in adolescence and risk of schizophrenia in adulthood: A prospective birth cohort study.Brain, behavior, and immunity · 2017Article
- Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study.Comprehensive psychiatry · 2016Article
- Is there a role for immune-to-brain communication in schizophrenia?Psychopharmacology · 2016Review
- Does Infection-Induced Immune Activation Contribute to Dementia?Aging and disease · 2015Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo determine neurocognitive, educational, and psychological functioning during childhood and early adolescence among survivors of early life meningitis who are apparently healthy.
methodsIn the general population-based Avon Longitudinal Study of Parents and Children birth cohort, meningitis exposure was determined at age of 18 months. The outcomes of intelligence quotient, short-term memory, working memory, reading and spelling abilities, psychological and behavioral problems, depressive and anxiety symptoms, and psychotic experiences at ages 9 to 13 years were compared between those exposed and unexposed to meningitis. Individuals with special educational needs were excluded.
resultsBy age of 18 months, 67 of 11,035 children were reported to have suffered from meningitis (0.61%). These children, compared with the unexposed, performed worse on all neurocognitive and educational measures; mean difference in total intelligence quotient 7.36 (95% confidence interval, 1.60-13.11). Meningitis was associated with higher depressive and anxiety symptoms (P = .02), psychological and behavioral problems (P = .09), and increased risk of psychotic experiences; risk ratio 2.22 (95% confidence interval, 1.12-4.38).
conclusionsExposure to meningitis in the early life is associated with neurocognitive, educational, and psychological difficulties during childhood and early adolescence among survivors who are apparently healthy. Therefore, focusing only on serious neurologic disabilities may underestimate the true impact of early life meningitis.
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