Evidence map›Paper›PMID 25794611›Full record

ArticleMolecular cell2015

Molecular toggle switch of histone demethylase LSD1.

Jaehoon Shin, Guo-Li Ming, Hongjun Song

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jaehoon ShinGraduate Program in Cellular and Molecular Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Institute for Cell Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Guo-Li MingGraduate Program in Cellular and Molecular Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Institute for Cell Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Hongjun SongGraduate Program in Cellular and Molecular Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Institute for Cell Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address: shongju1@jhmi.edu.
Johns Hopkins University · US

Funding

Translational models of neurodevelopmental epigenetics and disease using human iPSCsP01NS097206 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI HE, CHUAN · 2016 to 2020
$4.3M
Development of new neurons in the adult brainR01NS047344 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SONG, HONGJUN · 2003 to 2011
$3.4M
Calcium signaling in neuronal navigationR01NS048271 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MING, GUO-LI · 2004 to 2014
$3.2M
Circuitry mechanisms underlying normal and aberrant adult hippocampal neurogenesisR01MH105128 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI MING, GUO-LI · 2014 to 2018
$2.0M
Regulation of adult neurogenesis during agingR01AG024984 · NIA · JOHNS HOPKINS UNIVERSITY · PI SONG, HONGJUN · 2004 to 2008
$1.6M
Neurobiology of MeCP2 in adult neurogenesisR01HD069184 · NICHD · JOHNS HOPKINS UNIVERSITY · PI MING, GUO-LI · 2010 to 2012
$734k
NIA NIH HHS R01 AG024984NICHD NIH HHS R01 HD069184NIMH NIH HHS R01 MH105128NINDS NIH HHS P01 NS097206NINDS NIH HHS R01 NS047344NINDS NIH HHS R01 NS048271
6 · The paper itself

Abstract

In this issue of Molecular Cell, Laurent et al. (2015) demonstrated that a neuron-enriched isoform of LSD1 (LSD1+8a) within a SVIL-containing complex exhibits H3K9me1/2-specific demethylation activity. Such activity was crucial for gene activation during mammalian neurogenesis.

Indexed as

Histone DemethylasesHumansMembrane ProteinsMicrofilament ProteinsNeuronsHistone DemethylasesKDM1A protein, humanMembrane ProteinsMicrofilament ProteinsSVIL protein, human

Identifiers

PMID25794611
PMCPMC5476831
OpenAlexW2037869406

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.