ArticlePediatric nephrology (Berlin, Germany)2015
The impact of small kidneys.
Article in Pediatric nephrology (Berlin, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Review
- Pediatric Bilateral Hypoplastic Kidney Complicated With C1q Nephropathy: A Case Report.Cureus · 2024Article
- Hypertension in children with congenital anomalies of the kidney and urinary tract.Pediatric nephrology (Berlin, Germany) · 2024Article
- Congenital anomalies of the kidney and urinary tract: defining risk factors of disease progression and determinants of outcomes.Pediatric nephrology (Berlin, Germany) · 2023Review
- Predicting outcomes in children with congenital anomalies of the kidney and urinary tract.Pediatric nephrology (Berlin, Germany) · 2023Article
- Unilateral hypoplastic kidney in adults: An experience of a tertiary-level urology center.World journal of nephrology · 2022Article
- Outcomes of solitary functioning kidneys-renal agenesis is different than multicystic dysplastic kidney disease.Pediatric nephrology (Berlin, Germany) · 2021Article
- Primary causes of kidney disease and mortality in dialysis-dependent children.Pediatric nephrology (Berlin, Germany) · 2020Article
- The population-based prevalence of albuminuria in children.Pediatric nephrology (Berlin, Germany) · 2017Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSmall kidneys due to renal hypodysplasia (RHD) result from a decrease in nephron number. The objectives of this study were to identify clinical variables that determine long-term renal outcome in children with RHD and to define the role of kidney size as a predictor of developing end-stage renal disease (ESRD).
methodsThis was a single-center retrospective cohort analysis. The primary outcome was development of ESRD. We identified 202 RHD cases, with 25 (12%) reaching ESRD at mean age of 8.9 (±6.6) years.
resultsChildren with RHD with a known genetic syndrome had the smallest kidneys while those with posterior urethral valves (PUV) had the largest kidneys at diagnosis. Cases with bilateral RHD were most likely to develop ESRD. Younger gestational age (OR 0.8, CI 0.69-0.99, p = 0.05), smaller kidney size at diagnosis (OR 0.13, CI 0.03-0.47, p = 0.002), lower best-estimated glomerular filtration rate (eGFR) (OR 0.74, CI 0.58-0.93, p = 0.01), proteinuria (OR 1.03, CI 1.01-1.05, p < 0.001) and high blood pressure (OR 1.02, CI 1.01-1.04, p = 0.01) were associated with development of ESRD, while kidney size at diagnosis was independently associated with ESRD (HR 0.03, CI 0.01-0.72, p = 0.043).
conclusionsIn children with RHD, kidney size at diagnosis predicts the likelihood of developing ESRD.
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