Evidence map›Paper›PMID 25794494›Full record

ReviewClinical and experimental medicine2016

Expression of cell cycle and apoptosis regulators in thymus and thymic epithelial tumors.

Alexandra Papoudou-Bai, Alexandra Barbouti, Vassiliki Galani, Kalliopi Stefanaki, Dimitra Rontogianni, Panagiotis Kanavaros

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical and experimental medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Alexandra Papoudou-BaiDepartment of Pathology, University of Ioannina, Ioannina, Greece. apapoudoubai@gmail.com.
Alexandra BarboutiDepartment of Anatomy-Histology-Embryology, University of Ioannina, Ioannina, Greece.
Vassiliki GalaniDepartment of Anatomy-Histology-Embryology, University of Ioannina, Ioannina, Greece.
Kalliopi StefanakiDepartment of Pathology, Agia Sophia Children's Hospital, Athens, Greece.
Dimitra RontogianniDepartment of Pathology, Evangelismos Hospital, Athens, Greece.
Panagiotis KanavarosDepartment of Anatomy-Histology-Embryology, University of Ioannina, Ioannina, Greece. pkanavar@cc.uoi.gr.
University of Ioannina · GRChildren's Hospital Agia Sophia · GREvangelismos Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human thymus supports the production of self-tolerant T cells with competent and regulatory functions. Various cellular components of the thymic microenvironment such as thymic epithelial cells (TEC) and dendritic cells play essential roles in thymic T cell differentiation. The multiple cellular events occurring during thymic T cell and TEC differentiation involve proteins regulating cell cycle and apoptosis. Dysregulation of the cell cycle and apoptosis networks is involved in the pathogenesis of thymic epithelial tumors (TET) which are divided into two broad categories, thymomas and thymic carcinomas. The present review focuses on the usefulness of the analysis of the expression patterns of major cell cycle and apoptosis regulators in order to gain insight in the histophysiology of thymus and the histopathology, the clinical behavior and the biology of TET.

Indexed as

ApoptosisApoptosis Regulatory ProteinsCell Cycle ProteinsCell DifferentiationCell ProliferationGene Expression ProfilingHumansNeoplasms, Glandular and EpithelialThymus GlandThymus NeoplasmsApoptosis Regulatory ProteinsCell Cycle ProteinsApoptosisCell cycleThymic epithelial tumorsThymus

Identifiers

PMID25794494
OpenAlexW2075510507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.