Evidence map›Paper›PMID 25794276›Full record

ArticlePloS one2015

Comparison of normal saline, hypertonic saline albumin and terlipressin plus hypertonic saline albumin in an infant animal model of hypovolemic shock.

Javier Urbano, Rafael González, Jorge López, María J Solana, José M Bellón, Marta Botrán, Ana García, Sarah N Fernández, Jesús López-Herce

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Observational
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  3. Review
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Javier UrbanoPediatric Intensive Care Department, Gregorio Marañon University Hospital, Madrid, Spain, and Instituto de Investigación Sanitaria Hospital Gregorio Marañón (IiSGM), Research Network on Maternal and Child Health and Development (RedSAMID II), Spanish Health Institute Carlos III, Madrid, Spain; Health Research Fund, Spanish Health Institute Carlos III, Madrid, Spain.
Rafael GonzálezPediatric Intensive Care Department, Gregorio Marañon University Hospital, Madrid, Spain, and Instituto de Investigación Sanitaria Hospital Gregorio Marañón (IiSGM), Research Network on Maternal and Child Health and Development (RedSAMID II), Spanish Health Institute Carlos III, Madrid, Spain; Health Research Fund, Spanish Health Institute Carlos III, Madrid, Spain.
Jorge LópezPediatric Intensive Care Department, Gregorio Marañon University Hospital, Madrid, Spain, and Instituto de Investigación Sanitaria Hospital Gregorio Marañón (IiSGM), Research Network on Maternal and Child Health and Development (RedSAMID II), Spanish Health Institute Carlos III, Madrid, Spain; Health Research Fund, Spanish Health Institute Carlos III, Madrid, Spain.
María J SolanaPediatric Intensive Care Department, Gregorio Marañon University Hospital, Madrid, Spain, and Instituto de Investigación Sanitaria Hospital Gregorio Marañón (IiSGM), Research Network on Maternal and Child Health and Development (RedSAMID II), Spanish Health Institute Carlos III, Madrid, Spain.
José M BellónPreventive and Quality Control Service, Instituto de Investigación Sanitaria del Hospital Gregorio Marañón Madrid (IiSGM), Madrid, Spain.
Marta BotránPediatric Intensive Care Department, Gregorio Marañon University Hospital, Madrid, Spain, and Instituto de Investigación Sanitaria Hospital Gregorio Marañón (IiSGM), Research Network on Maternal and Child Health and Development (RedSAMID II), Spanish Health Institute Carlos III, Madrid, Spain.
Ana GarcíaPediatric Intensive Care Department, Gregorio Marañon University Hospital, Madrid, Spain, and Instituto de Investigación Sanitaria Hospital Gregorio Marañón (IiSGM), Research Network on Maternal and Child Health and Development (RedSAMID II), Spanish Health Institute Carlos III, Madrid, Spain.
Sarah N FernándezPediatric Intensive Care Department, Gregorio Marañon University Hospital, Madrid, Spain, and Instituto de Investigación Sanitaria Hospital Gregorio Marañón (IiSGM), Research Network on Maternal and Child Health and Development (RedSAMID II), Spanish Health Institute Carlos III, Madrid, Spain.
Jesús López-HercePediatric Intensive Care Department, Gregorio Marañon University Hospital, Madrid, Spain, and Instituto de Investigación Sanitaria Hospital Gregorio Marañón (IiSGM), Research Network on Maternal and Child Health and Development (RedSAMID II), Spanish Health Institute Carlos III, Madrid, Spain; Health Research Fund, Spanish Health Institute Carlos III, Madrid, Spain.
Hospital General Universitario Gregorio Marañón · ESInstituto de Salud Carlos III · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn series of cases and animal models suffering hemorrhagic shock, the use of vasopressors has shown potential benefits regarding hemodynamics and tissue perfusion. Terlipressin is an analogue of vasopressin with a longer half-life that can be administered by bolus injection. We have previously observed that hypertonic albumin improves resuscitation following controlled hemorrhage in piglets. The aim of the present study was to analyze whether the treatment with the combination of terlipressin and hypertonic albumin can produce better hemodynamic and tissular perfusion parameters than normal saline or hypertonic albumin alone at early stages of hemorrhagic shock in an infant animal model.

methodsExperimental, randomized animal study including 39 2-to-3-month-old piglets. Thirty minutes after controlled 30 ml/kg bleed, pigs were randomized to receive either normal saline (NS) 30 ml/kg (n = 13), 5% albumin plus 3% hypertonic saline (AHS) 15 ml/kg (n = 13) or single bolus of terlipressin 15 μg/kg i.v. plus 5% albumin plus 3% hypertonic saline 15 ml/kg (TAHS) (n = 13) over 30 minutes. Global hemodynamic and tissular perfusion parameters were compared.

resultsAfter controlled bleed a significant decrease of blood pressure, cardiac index, central venous saturation, carotid and peripheral blood flow, brain saturation and an increase of heart rate, gastric PCO2 and lactate was observed. After treatment no significant differences in most hemodynamic (cardiac index, mean arterial pressure) and perfusion parameters (lactate, gastric PCO2, brain saturation, cutaneous blood flow) were observed between the three therapeutic groups. AHS and TAHS produced higher increase in stroke volume index and carotid blood flow than NS.

conclusionsIn this pediatric animal model of hypovolemic shock, albumin plus hypertonic saline with or without terlipressin achieved similar hemodynamics and perfusion parameters than twice the volume of NS. Addition of terlipressin did not produce better results than AHS.

Indexed as

AlbuminsAnimalsAnimals, NewbornBlood PressureCarbon DioxideDisease Models, AnimalHeart RateHemodynamicsHemorrhageHypovolemiaLypressinOxygenSaline Solution, HypertonicSodium ChlorideStroke VolumeSus scrofaAlbuminsCarbon DioxideLypressinOxygenSaline Solution, HypertonicSodium ChlorideTerlipressin

Identifiers

PMID25794276
PMCPMC4368553
OpenAlexW2070308469

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.