Trial reportPediatric research2015
Early formation of bilirubin isomers during phototherapy for neonatal jaundice: effects of single vs. double fluorescent lamps vs. photodiodes.
Trial report in Pediatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- High- versus low-dose phototherapy for neonatal jaundice.The Cochrane database of systematic reviews · 2026Pooled it
- Bilirubin isomers during LED phototherapy of hyperbilirubinemic neonates, blue-green (~478 nm) vs blue.Pediatric research · 2025Trial
- Double versus single intensive phototherapy with LEDs in treatment of neonatal hyperbilirubinemia.Journal of perinatology : official journal of the California Perinatal Association · 2018Trial
- Bilirubin isomer distribution in jaundiced neonates during phototherapy with LED light centered at 497 nm (turquoise) vs. 459 nm (blue).Pediatric research · 2016Trial
- Review
- A graphene oxide/polyaniline nanocomposite biosensor: synthesis, characterization, and electrochemical detection of bilirubin.RSC advances · 2023Article
- A zebrafish model for studying the mechanisms of newborn hyperbilirubinemia and bilirubin-induced neurological damage.Frontiers in cell and developmental biology · 2023Article
- Phototherapy in dermatological maladies (Review).Experimental and therapeutic medicine · 2022Review
- Sixty years of phototherapy for neonatal jaundice - from serendipitous observation to standardized treatment and rescue for millions.Journal of perinatology : official journal of the California Perinatal Association · 2020Review
- LED Photo-polymerization, a Novel Strategy for Triggered Release Liposomes.Iranian journal of pharmaceutical research : IJPR · 2020Article
- Analysis of therapeutic effect of intermittent and continuous phototherapy on neonatal hemolytic jaundice.Experimental and therapeutic medicine · 2019Article
- The impact of hemoglobin on the efficacy of phototherapy in hyperbilirubinemic infants.Pediatric research · 2017Article
- The effect of hematocrit on in vitro bilirubin photoalteration.Pediatric research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn neonatal jaundice, phototherapy converts bilirubin to more polar photoisomers which can be excreted without conjugation. We measured changes in the concentration of bilirubin Z,E-photoisomer during the first 4 h of intensive phototherapy using single fluorescent lights as a reference, compared to double fluorescent lights, and a single unit of photodiodes.
methodsNeonates (N = 42; birth weight: 1,200-4,690 g; gestational age: 28-42 wk) were studied during phototherapy. Infants were randomized to: (i) single, or (ii) double fluorescent phototherapy; or (iii) single unit photodiodes. Irradiance was measured. Serum bilirubin (by cooximetry) and Z,E bilirubin (by high-pressure liquid chromatography) were measured at 0,15, 30, 60, 120, and 240 min after the start of phototherapy. Data were analyzed with a linear mixed model.
resultsThere was a highly significant increase of Z,E-bilirubin over time (P < 0.0001), starting at 15 min. Photoisomers reached ~25% of total bilirubin concentration after 4 h. However, there were no significant differences between the three randomized groups in spite of significantly higher irradiance using double fluorescent lights vs. single fluorescent or photodiodes.
conclusionFormation of bilirubin photoisomers is rapid, and occurs early during intensive phototherapy for neonatal jaundice. The rate and level of photoisomerization was not influenced by irradiance and light source.
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Registered trials
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