ArticlePloS one2015
Characterization of monoclonal gammopathy of undetermined significance by calorimetric analysis of blood serum proteome.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Development of Autologous Serum Ocular Insert for Chronic Dry Eye Disease.Pharmaceutics · 2026Article
- Article
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- Red Blood Cells' Thermodynamic Behavior in Neurodegenerative Pathologies and Aging.Biomolecules · 2021Article
- Calorimetric markers for monitoring of multiple myeloma and Waldenström's macroglobulinemia patients.European biophysics journal : EBJ · 2018Article
- MALDI-TOF analysis of blood serum proteome can predict the presence of monoclonal gammopathy of undetermined significance.PloS one · 2018Article
- Blood Serum Calorimetry Indicates the Chemotherapeutic Efficacy in Lung Cancer Treatment.Scientific reports · 2017Article
- Application and interpretation of functional data analysis techniques to differential scanning calorimetry data from lupus patients.PloS one · 2017Article
- Differential scanning calorimetry as a complementary diagnostic tool for the evaluation of biological samples.Biochimica et biophysica acta · 2016Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant proliferative disorder that may progress to multiple myeloma, a malignant plasma cell neoplasia. We evaluated differential scanning calorimetry (DSC) as an experimental tool for differentiating serum samples of MGUS patients from healthy individuals. DSC thermograms can be used for monitoring changes in the serum proteome associated with MGUS. MGUS patients showed great variability in serum thermogram characteristics, which depended on the IgG, IgA or IgM isotypes and/or the κ or λ light chains. Thermogram feature parameters distinguished patients with MGUS from healthy people. Serum samples, named as non-MGUS, were also collected from patients with subjacent immunological pathologies who were discarded of having MGUS through serum immunofixation. They were used to verify the sensitivity of DSC for discriminating MGUS from related blood dyscrasias. Only some DSC thermogram feature parameters differentiated, to a lesser extent, between MGUS and non-MGUS individuals. We contemplate DSC as a tool for early diagnosis and monitoring of MGUS.
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