Evidence map›Paper›PMID 25793753›Full record

Trial reportPloS one2015

Endurance training-induced increase in circulating irisin levels is associated with reduction of abdominal visceral fat in middle-aged and older adults.

Eri Miyamoto-Mikami, Koji Sato, Toshiyuki Kurihara, Natsuki Hasegawa, Shumpei Fujie, Satoshi Fujita, Kiyoshi Sanada, Takafumi Hamaoka, Izumi Tabata, Motoyuki Iemitsu

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  18. Skeletal Muscle as Endocrine Organ.Advances in experimental medicine and biology · 2025
    Review
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  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eri Miyamoto-MikamiFaculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan; Japan Society for the Promotion of Science, Tokyo, Japan.
Koji SatoFaculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
Toshiyuki KuriharaFaculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
Natsuki HasegawaFaculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
Shumpei FujieFaculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
Satoshi FujitaFaculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
Kiyoshi SanadaFaculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
Takafumi HamaokaFaculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
Izumi TabataFaculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
Motoyuki IemitsuFaculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To elucidate the effects of endurance training on circulating irisin levels in young and middle-aged/older adults, and to determine the association between endurance training-induced alteration of irisin and reduction in body fat. Twenty-five healthy young (age 21 ± 1 years; 16 men, 9 women) and 28 healthy middle-aged/older adults (age 67 ± 8 years; 12 men, 16 women) participated in the study. Each age cohort was divided into two groups: the endurance-training group (14 young, 14 middle-aged/older) and the control group. Subjects in the training groups completed an 8-week endurance-training program (cycling at 60-70% peak oxygen uptake [V̇O2peak] for 45 min, 3 days/week). Before and after the intervention, we evaluated serum irisin level, V̇O2peak, and body composition. The increase in V̇O2peak in the young and middle-aged/older training groups after the intervention period was significantly greater than those in the young and middle-aged/older control groups (P < 0.05). Serum irisin level was significantly increased in the middle-aged/older training group after the intervention period (P < 0.01), but not in the young training group. Furthermore, in the middle-aged/older training group, the endurance training-induced reduction in visceral adipose tissue area was negatively correlated with the change in serum irisin level (r = -0.54, P < 0.05). These results suggest a possible role for secreted irisin in the exercise-induced alteration of abdominal visceral fat in middle-aged and older adults.

Indexed as

Physical EnduranceAgedBody CompositionBody WeightCase-Control StudiesFemaleFibronectinsHumansIntra-Abdominal FatMaleMiddle AgedYoung AdultFibronectinsFNDC5 protein, human

Identifiers

PMID25793753
PMCPMC4368602

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.