ArticlePloS one2015
An examination of the association between 5-HTTLPR, combat exposure, and PTSD diagnosis among U.S. veterans.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- A Case-Control Study and Meta-Analysis Reveal BDNF Val66Met Is a Possible Risk Factor for PTSD.Neural plasticity · 2016Pooled it
- Novel GxE effects and resilience: A case:control longitudinal study of psychosocial stress with war-affected youth.PloS one · 2022Trial
- Prominent genetic variants and epigenetic changes in post-traumatic stress disorder among combat veterans.Molecular biology reports · 2024Review
- Correlation betweenTranslational pediatrics · 2022Article
- Review
- Understanding the Scientific Basis of Post-traumatic Stress Disorder (PTSD): Precision Behavioral Management Overrides Stigmatization.Molecular neurobiology · 2019Review
- A genome-wide association study of suicide attempts and suicidal ideation in U.S. military veterans.Psychiatry research · 2018Article
- Gene × Environment Interaction in Developmental Disorders: Where Do We Stand and What's Next?Frontiers in psychology · 2018Article
- The Post-Deployment Mental Health (PDMH) study and repository: A multi-site study of US Afghanistan and Iraq era veterans.International journal of methods in psychiatric research · 2017Article
- Decreased uncinate fasciculus tract integrity in male and female patients with PTSD: a diffusion tensor imaging study.Journal of psychiatry & neuroscience : JPN · 2017Article
- Genetic approaches for the study of PTSD: Advances and challenges.Neuroscience letters · 2017Review
- PTSD, alcohol dependence, and conduct problems: Distinct pathways via lability and disinhibition.Addictive behaviors · 2017Article
- Analysis of the Serotonergic System in a Mouse Model of Rett Syndrome Reveals Unusual Upregulation of Serotonin Receptor 5b.Frontiers in molecular neuroscience · 2017Article
- The Effects of a BDNF Val66Met Polymorphism on Posttraumatic Stress Disorder: A Meta-Analysis.Neuropsychobiology · 2017Article
- Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder.Psychiatry research · 2015Article
- Association of 5-HTTLPR With Post-Traumatic Stress Disorder in US Service Members.Chronic stress (Thousand Oaks, Calif.)Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveTo examine the association between the 5-HTTLPR polymorphism of the serotonin transporter (SLC6A4) gene, combat exposure, and posttraumatic stress disorder (PTSD) diagnosis and among two samples of combat-exposed veterans.
methodThe first sample included 550 non-Hispanic Black (NHB) combat-exposed veterans. The second sample included 555 non-Hispanic White (NHW) combat-exposed veterans. Participants were genotyped for the 5-HTTLPR/rs25531 variants of the SLC6A4 gene. A structured clinical interview was used to diagnose PTSD. Combat and civilian trauma exposure were assessed with validated self-report instruments. Logistic regression was used to test for main effects of 5-HTTLPR on PTSD diagnosis as well as gene x environment (GxE) interactions after adjusting for sex, ancestry proportion scores, civilian trauma exposure, and combat exposure.
resultsWithin the NHB sample, a significant additive effect was observed for 5-HTTLPR (OR = 1.502, p = .0025), such that the odds of having a current diagnosis of PTSD increased by 1.502 for each additional S' allele. No evidence for an association between 5-HTTLPR and PTSD was observed in the NHW sample. In addition, no evidence for combat x 5-HTTLPR effects were observed in either sample.
conclusionThe present study suggests that there may be an association between 5-HTTLPR genotype and PTSD diagnosis among NHB veterans; however, no evidence for the hypothesized 5-HTTLPR x combat interaction was found.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.