Evidence map›Paper›PMID 25793653›Full record

Trial reportJournal of computer assisted tomography

Texture Analysis of Non-Contrast-Enhanced Computed Tomography for Assessing Angiogenesis and Survival of Soft Tissue Sarcoma.

Koichi Hayano, Fang Tian, Avinash R Kambadakone, Sam S Yoon, Dan G Duda, Balaji Ganeshan, Dushyant V Sahani

Abstract readClinical Trial, Phase II
In one paragraph

Trial report in Journal of computer assisted tomography. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Koichi HayanoFrom the *Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA; †Department of Radiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; ‡Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY; §Steele Laboratory, Massachusetts General Hospital, Boston, MA; and ∥Institute of Nuclear Medicine, University College London, UK.
Fang Tian
Avinash R Kambadakone
Sam S Yoon
Dan G Duda
Balaji Ganeshan
Dushyant V Sahani

Funding

HIFs and VEGF in sarcoma progression, metastasis, and radiation responseR01CA158301 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SIMON, M. CELESTE, YOON, SAM SUNGHYUN · 2011 to 2021
$4.1M
Bevacizumab and radiation therapy for sarcomasR21CA117128 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI YOON, SAM SUNGHYUN · 2006 to 2007
$637k
NCI NIH HHS 1R01 CA158301NCI NIH HHS 1 R21 CA117128NCI NIH HHS R01 CA158301NCI NIH HHS R21 CA117128
6 · The paper itself

Abstract

objectiveTo evaluate the role of computed tomographic (CT) texture analysis in assessing tumor angiogenesis and survival of soft tissue sarcoma (STS).

methodsIn 20 patients with STSs, tumor texture parameters, which were measured on pretherapeutic CT using CT texture analysis software with the spatial scale filter extracting fine to coarse texture, were compared with microvessel density, plasma vascular endothelial growth factor (VEGF), soluble VEGF receptor-1, and overall survival (OS).

resultsMean of positive pixels (MPP) showed a positive correlation with microvessel density (P = 0.02). Entropy at medium texture scales (spatial scale filter = 3, 4, 5) showed positive correlations with VEGF (P = 0.03, P = 0.009, and P = 0.02, respectively), and entropy without filtration showed a positive correlation with soluble VEGF receptor-1 (P = 0.02). In the univariate analysis, kurtosis at a medium texture scale and MPP showed significant correlations with OS (P = 0.04 and P = 0.007), and multivariate analysis demonstrated that MPP was an independent prognostic factor (P = 0.01).

conclusionTexture parameters are associated with tumor angiogenesis and OS in STS.

Indexed as

Multidetector Computed TomographyAdultAgedBiomarkersFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoadjuvant TherapyNeovascularization, PathologicObserver VariationSarcomaSurvival AnalysisVascular Endothelial Growth Factor ABiomarkersVascular Endothelial Growth Factor A

Identifiers

PMID25793653
PMCPMC4504795

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.