ArticlePloS one2015
Suppression of TGF-β1/Smad signaling pathway by sesamin contributes to the attenuation of myocardial fibrosis in spontaneously hypertensive rats.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Menstrual blood-derived stromal cells exhibit superior protection against lung injury in myocardial Infarction-Induced heart failure in rats compared to bone marrow-derived stromal cells.Regenerative therapy · 2026Article
- Dietary niacin intake and mortality outcomes in hypertensive populations: analysis from NHANES 2003-2016.Journal of health, population, and nutrition · 2025Article
- Effects of sesame (Food science & nutrition · 2023Review
- Lactacystin-induced kidney fibrosis: Protection by melatonin and captopril.Frontiers in pharmacology · 2022Article
- Atorvastatin attenuates TGF‑β1‑induced fibrogenesis by inhibiting Smad3 and MAPK signaling in human ventricular fibroblasts.International journal of molecular medicine · 2020Article
- Various aspects of inflammation in heart failure.Heart failure reviews · 2020Review
- Review
- MicroRNA-663 participates in myocardial fibrosis through interaction with TGF-β1.Experimental and therapeutic medicine · 2019Article
- Sesame Oil Attenuates Renal Oxidative Stress Induced by a High Fat Diet.Preventive nutrition and food science · 2019Article
- Protective effect of Qishen Yiqi dropping pills on the myocardium of rats with chronic heart failure.Experimental and therapeutic medicine · 2019Article
- Regulatory Effect of 1,25(OH)2D3 on TGF-International journal of endocrinology · 2019Article
- Integrin ανβ5 in vitro inhibition limits pro-fibrotic response in cardiac fibroblasts of spontaneously hypertensive rats.Journal of translational medicine · 2018Article
- Epigallocatechingallate attenuates myocardial injury in a mouse model of heart failure through TGF‑β1/Smad3 signaling pathway.Molecular medicine reports · 2018Article
- Sitagliptin ameliorates diabetic nephropathy by blocking TGF-β1/Smad signaling pathway.International journal of molecular medicine · 2018Article
- Ginsenoside Rb1 improves cardiac function and remodeling in heart failure.Experimental animals · 2017Article
- The expression of Smad signaling pathway in myocardium and potential therapeutic effects.Histology and histopathology · 2017Review
- C1q/TNF-Related Protein 3 (CTRP3) Function and Regulation.Comprehensive Physiology · 2017Review
- Traditional Chinese medicine baoxin decoction improves cardiac fibrosis of rats with dilated cardiomyopathy.Experimental and therapeutic medicine · 2017Article
- Angiotensinase C mRNA and Protein Downregulations Are Involved in Ethanol-Deteriorated Left Ventricular Systolic Dysfunction in Spontaneously Hypertensive Rats.BioMed research international · 2015Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the effect of sesamin on myocardial fibrosis in spontaneously hypertensive rats (SHRs) and the possible mechanisms involved. Twenty-eight male SHRs were randomly allocated to SHR group, Ses160 group (sesamin 160 mg/kg), Ses80 group (sesamin 80 mg/kg) and Cap30 group (captopril 30 mg/kg). Seven male WKY rats were used as control. Sesamin and captopril were administered intragastrically for 12 weeks. Captopril significantly reduced systolic blood pressure and angiotensin II (Ang II) levels in SHRs, accompanied by a marked attenuation of left ventricular hypertrophy (LVH) and collagen deposition (P <0.05 or P <0.01). Though sesamin had no significant influence on Ang II levels, and the hypotensive effect was also significantly inferior to that of captopril (P <0.05 or P <0.01), however, the improvement of LVH and collagen deposition was similar to that in captopril group. Sesamin markedly reduced transforming growth factor-β1 (TGF-β1) content in cardiac tissues, with Smad3 phosphorylation decreased and Smad7 protein expression increased notably (P <0.05 or P <0.01). Protein expression of type I collagen and type III collagen, target genes of Smad3, was down-regulated markedly by sesamin (P <0.05 or P <0.01). In addition, sesamin significantly increased total antioxidant capacity and superoxide dismutase protein in cardiac tissues (P <0.05 or P <0.01), while the expression of NADPH oxidase subunit p47phox and malondialdehyde content were reduced markedly (P <0.05 or P <0.01). In vitro studies also demonstrated that sesamin was able to suppress Ang II induced phosphorylation of Smad3 and secretion of TGF-β1 and type I and type III collagen in cultured rat cardiac fibroblasts. These data suggest that sesamin is capable of attenuating hypertensive myocardial fibrosis through, at least partly, suppression of TGF-β1/Smad signaling pathway.
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