Evidence map›Paper›PMID 25793439›Full record

ReviewTransplantation2015

Pericytes, microvasular dysfunction, and chronic rejection.

Malgorzata Kloc, Jacek Z Kubiak, Xian C Li, Rafik M Ghobrial

Open access · greenAbstract readReview
In one paragraph

Review in Transplantation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
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  6. Article
  7. Review
  8. Article
  9. Article
  10. AdvancedFrontiers in immunology · 2021
    Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Natural products against cancer angiogenesis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Review
  17. Lung Pericytes and Resident Fibroblasts: Busy Multitaskers.The American journal of pathology · 2016
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Malgorzata Kloc1 The Houston Methodist Research Institute, Houston, TX. 2 CNRS/University Rennes1 UMR 6290, Institute of Genetics and Development of Rennes, Cell Cycle Group, Faculty of Medicine, 35-043 Rennes, France.
Jacek Z Kubiak
Xian C Li
Rafik M Ghobrial
Houston Methodist · US

Funding

Modulation of innate immune cells to create transplant toleranceR01AI080779 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI Xian Chang Li · 2011 to 2026
$5.2M
NIAID NIH HHS R01 AI080779NIAID NIH HHS R01AI 080779A2
6 · The paper itself

Abstract

Chronic rejection of transplanted organs remains the main obstacle in the long-term success of organ transplantation. Thus, there is a persistent quest for development of antichronic rejection therapies and identification of novel molecular and cellular targets. One of the potential targets is the pericytes, the mural cells of microvessels, which regulate microvascular permeability, development, and maturation by controlling endothelial cell functions and regulating tissue fibrosis and inflammatory response. In this review, we discuss the potential of targeting pericytes in the development of microvasular dysfunction and the molecular pathways involved in regulation of pericyte activities for antichronic rejection intervention.

Indexed as

MicrocirculationAngiogenic ProteinsAnimalsCell CommunicationCell TransdifferentiationChronic DiseaseEndothelial CellsFibrosisGraft RejectionHumansInflammation MediatorsMicrovesselsMyocytes, Smooth MuscleOrgan TransplantationPericytesSignal TransductionAngiogenic ProteinsInflammation Mediators

Identifiers

PMID25793439
PMCPMC4455035
OpenAlexW1990783176

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.