ArticlePloS one2015
Genetic structure analysis of Spirometra erinaceieuropaei isolates from central and southern China.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Phylogenetic Inference and Ancestral Character Reconstruction of Diphyllobothriid Tapeworms (Cestoda: Diphyllobothriidae).Animals : an open access journal from MDPI · 2026Article
- Deciphering the global genetic structure of Spirometra mansoni and S. erinaceieuropaei based on 28S ribosomal RNA: Insights into taxonomical revaluation and population dynamics.Parasitology research · 2025Article
- Epidemiology, Diagnosis, and Prevention of Sparganosis in Asia.Animals : an open access journal from MDPI · 2022Review
- Case Report: Morphologic and Genetic Identification of Cerebral Sparganosis.The American journal of tropical medicine and hygiene · 2019Article
- Mitochondrial DNA Sequence Variability of Spirometra Species in Asian Countries.The Korean journal of parasitology · 2019Article
- Broad tapeworms (Diphyllobothriidae), parasites of wildlife and humans: Recent progress and future challenges.International journal for parasitology. Parasites and wildlife · 2019Review
- Genetic Identification of Spirometra erinaceieuropaei Spargana in Liaoning and Hubei Provinces, PR China.The Korean journal of parasitology · 2019Article
- Multiple zoonotic helminth infections in domestic dogs in a rural area of Khuzestan Province in Iran.BMC veterinary research · 2018Article
- A neglected risk for sparganosis: eating live tadpoles in central China.Infectious diseases of poverty · 2017Article
- Molecular Identification of Spirometra erinaceieuropaei Tapeworm in Cases of Human Sparganosis, Hong Kong.Emerging infectious diseases · 2017Article
- Molecular cloning and characterization of a Spirometra erinacei casein kinase I.Parasitology research · 2015Article
- Genetic diversity of Trichomonas vaginalis clinical isolates from Henan province in central China.Pathogens and global health · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSparganosis caused by invasion of the plerocercoid larvae (spargana) of Spirometra erinaceieuropaei have increased in recent years in China. However, the population genetic structure regarding this parasite is still unclear. In this study, we used the sequences of two mitochondrial genes cytochrome b (cytb) and cytochrome c oxidase subunit I (cox1) to analyze genetic variation and phylogeographic structure of the S. erinaceieuropaei populations. METHODOLOGY/PRINCIPAL
findingsA total of 88 S. erinaceieuropaei isolates were collected from naturally infected frogs in 14 geographical locations of China. The complete cytb and cox1 genes of each sample was amplified and sequenced. Total 61 haplotypes were found in these 88 concatenated sequences. Each sampled population and the total population have high haplotype diversity (Hd), accompanied by very low nucleotide diversity (Pi). Phylogenetic analyses of haplotypes revealed two distinct clades (HeN+HuN+GZ-AS clade and GX+HN+GZ-GY clade) corresponding two sub-networks yielded by the median-joining network. Pairwise FST values supported great genetic differentiation between S. erinaceieuropaei populations. Both negative Fu's FS value of neutrality tests and unimodal curve of mismatch distribution analyses supported demographic population expansion in the HeN+HuN+GZ-AS clade. The BEAST analysis showed that the divergence time between the two clades took place in the early Pleistocene (1.16 Myr), and by Bayesian skyline plot (BSP) an expansion occurred after about 0.3 Myr ago.
conclusionsS. erinaceieuropaei from central and southern China has significant phylogeographic structure, and climatic oscillations during glacial periods in the Quaternary may affect the demography and diversification of this species.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.