ArticleIranian journal of pediatrics2014
Mean platelet volume as a negative marker of inflammation in children with rotavirus gastroenteritis.
Article in Iranian journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 29 citations in OpenAlex.
- Prediction of urinary tract infection using machine learning methods: a study for finding the most-informative variables.BMC medical informatics and decision making · 2025Article
- Comparative analysis of adenovirus and rotavirus gastroenteritis: insights into inflammatory response and temporal variations.Frontiers in pediatrics · 2025Article
- Salivary C-reactive protein and mean platelet volume as possible diagnostic markers for late-onset neonatal pneumonia.World journal of clinical pediatrics · 2024Article
- Evaluation of hematological indices of childhood illnesses in Tamale Metropolis of Ghana.Journal of clinical laboratory analysis · 2018Article
- Mean platelet volume in young children with urinary tract infection.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMean platelet volume (MPV) is a determinant of inflammation. The aim of the present study was to investigate the MPV levels in children with rotavirus gastroenteritis and to evaluate the possible relationship between MPV and severity of gastroenteritis.
methodsChildren diagnosed with acute rotavirus gastroenteritis and healthy controls were enrolled in this study. Patients were classified into three disease severity groups based on their Vesikari score (<7 mild, 7-10 moderate and >11 severe). Rotavirus was determined in fresh stool samples using ELISA test. Leukocyte and platelet counts, MPV and C-reactive protein (CRP) levels were assessed for all children.
findingsA total of 151 patients with rotavirus gastroenteritis (mean age 2.41± 0.14 years) and 80 healthy controls (mean age 2.63±0.22 years, P=0.129) were enrolled. MPV levels of children with rotavirus gastroenteritis were significantly lower than those of healthy peers (7.48±0.04 vs 7.79±0.07 fl, P=0.000). MPV levels were not significantly different among three gastroenteritis groups. Gastroenteritis score was positively correlated with leukocyte (r=0.670, P<0.01) and platelet count (r=0.159, P<0.05) and CRP level (r=0.256, P<0.01) in patients group. MPV was inversely correlated with platelet count. There was no significant correlation between MPV and gastroenteritis score.
conclusionMPV levels were significantly lower in children with rotavirus gastroenteritis compared to controls. MPV can be used as a negative acute phase reactant in children with rotavirus gastroenteritis.
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Identifiers
25793071PMC4359417W1870519400What OpenQuestion holds
Registered trials
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